We show for the first time ( in vitro and in vivo ) the beneficial effects of specific Nutrients like Vit B6 and and Vit A in the diabetic milieu , to ameliorate and restore β cell health and enhance neogenesis( increased formation of newer islet like cell clusters) ,being very critical for islet cell mass.
Using Prediabetic model systems , we have been able to demonstrate in vivo beneficial effects of Mesenchymal Stem Cells /MSCs ( Tx) to negate HOMA-IR , inflammation, Adiponectin to Leptin ratio and Glu Transporters with beneficial effects noted in visceral adipose depots. Further, immunomodulatory effects of MSCs have also been appreciable in cartilage repair and regeneration, when administered in combination with the sterols studied in chronic Obesity .
Active research is also being pursued to understand cellular and molecular mechanism(s) both in vitro and in vivo the effects of phytoestrogens vis a vis nutraceuticals to address the bone health , in addition to research on lead toxicity.
Cancer stem cells and Micronutrient research is an emerging area to comprehend their anti-oxidative ,anti-inflammatory and anti-proliferative effects in combination with Metformin .
The Molecular Biology Division is involved in understanding the molecular mechanisms of development of nutritional disorders like obesity and diabetes, zinc deficiency, nutrient transport through placenta. Using a diet-induced obesity model, they have shown infiltration and cross-talk of T cells with adipose tissue. Using cutting edge technologies like NGS and realtime PCR, they are trying to understand gene-nutrient and gene-gene interaction during development of these nutritional disorders. They are also studying how the metabolic stress is translated into inflammation at the endoplasmic reticulum into ER stress. They are also working towards development of early molecular biomarkers for diabetes, zinc deficiency by studying the circulating miRNA profiles in different cohorts using NGS. They are also studying the impact of glucose and fatty acids for placental development during gestation. They demonstrated that DHA (docosahexaenoic acid) stimulates the synthesis of angiogenic factor VEGF with concomitant increase in angiogenesis of the placental cells. Since, glucose acts as an energy substrate for developing a fetus, optimal glucose transporter-1 activity is required for the growth and development of the placenta which reduces IUGR. In addition, they are also studying host-pathogen interaction and role of gene-nutrient interactions in defining the outcome of an infection.