SCIENTIST 'B'
Biochemistry


Email:  sudhakarnin@gmail.com
Contact:  +91-40-27197293

Brief Profile
I received M.Sc. Genetics from Osmania University in 2008 and PhD, Biochemistry from Osmania University in 2015. I did postdoctoral research at the Cincinnati Children’s Hospital & Medical Center (CCHMC) in the area of Cystic Fibrosis for short span. Then, I joined the National Institute of Nutrition in November 2016 as a Scientist-B. My research interests include understanding the impact of dietary factors and functional foods in metabolic disorders including diabetes and obesity.  In addition, I am also working on to understand role of heat shock proteins, mini chaperones and proteostasis pathways in diabetes and obesity.

Total publications : 13; Publications in last 10 years
  1. Reddy, VS., Raghu, G., Reddy, SS., Kumar, PA., Suryanarayana, P., & Reddy, GB. Response of Small Heat Shock Proteins in diabetic rat retina. Invest Ophthalmol Vis Sci, 2013 Nov 19;54(12):7674-82(PMID-24159092).

  2. Reddy, VS., Kumar, CU., & Reddy, GB. Effect of Chronic Hyperglycemia on crystallin levels in rat lens. Biochem Biophys Res Commun, 2014 Apr 4; 446(2):602-7.(PMID-24632206)

  3. Reddy, VS., Kumar, CU., Raghu, G., & Reddy, GB. Expression and Induction of Small Heat Shock Proteins in rat heart under chronic hyperglycemic conditions. Arch Biochem Biophys. 2014 Sep 15; 558:1-9. (PMID-24950024)

  4. Reddy, VS., & Reddy, GB. Emerging role for αB-crystallin as a therapeutic agent: pros and cons. Curr Mol Med, 2015; 15(1):47-61. (PMID-25601468)

  5. Reddy, VS., Jakhotia, S., Reddy, PY., &Reddy, GB. Hyperglycemia induced expression, phosphorylation, and translocation of αB-crystallin in rat skeletal muscle.IUBMB Life, 2015 Apr; 67(4):291-9. (PMID-25900025)

  6. Reddy, VS., & Reddy, GB. Role of crystallins in diabetic complications.Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):269-77 (PMID-25988654).

  7. Vakdevi, V., Reddy, VS., Srinivas, PNBS., Mueller, NH., Bhagyalaxmi, SG., Padma,T., Petrash, JM., &     Reddy, GB.Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: Molecular basis for early onset of age-related cataract. FEBS letters, 2011 Dec 15; 585(24):3884-9. (PMID-22085609).

  8. Reddy, SS., Shruthi, K., Reddy, VS., Raghu, G., Suryanarayana, P., Giridhiran, N., & Reddy, GB. Altered ubiquitin proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochim Biophys Acta, 2014 Sep;1840(9):2924-34. (PMID-24949983).

  9. Shrivastava, S., Jeengar, MK., Reddy, VS., Reddy, GB.,& Naidu, VG. Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways.Exp Mol Pathol, 2015 Jun;98(3):313-27(PMID-25818165).

  10. Moon, C., Zhang, W., Sundaram, N., Yarlagadda, S., Reddy, VS., Arora, K., Helmrath, MA.,Naren, AP. Drug-induced secretory Diarrhea: A role for CFTR. Pharmacol Res. 2015 Dec; 102:107-12. (PMID-26429773).

  11. Noolu B, Gogulothu R, Bhat M, Qadri SS, Reddy VS, Reddy GB, Ismail A. In vivo inhibition of Proteasome activity and tumor growth by Murrayakoenigii leaf extract in breast cancer xenografts and by its active flavonoids in breast cancer cell lines. Anticancer Agents Med Chem.  2016; 16(12):1605-1614.(PMID-27198988).

  12. Raghu G, Akileshwari C, Reddy VS, Reddy GB. Attenuation of diabetic retinopathy in rats by ellagic acid through inhibition of AGE formation. J Food Sci Technol.2017 Jul;54(8):2411-2421 (PMID-28740299).

  13. Reddy VS*, Madala SK, Jamma T, Reddy GB*. Extracellular small heat shock proteins: Exosomal Biogenesis and Function. Cell Stress and Chaperones. 2018 May; 23 (3):441-454, DOI 10.1007/s12192-017-0856 (PMID-29086335) (equal corresponding Author).

Awards and Honors
  1. JRF Award by Indian Council of Medical Research
  2. JRF and Lectureship Award by UGC
  3. SRF Award by UGC
  4. Certificate of Merit for Oral Presentation in Asia-ARVO, New Delhi. October 28-31, 2013
  5. International Travel Grant award by DST-SERB
  6. N-PDF award by SERB
  7. Dr.D.S. Kothari Postdoctoral fellowship award by UGC
  8. Early Career Research Awar