Scientist ‘G’ & HoD (Sr. Deputy Director) 
Food safety

Email:   alkhandare@yahoo.com

Contact:   +91-40-27197325

Brief Profile

Joined NIN on permanent post of Research officer in 1995 after completion of my Ph.D in Biochemistry from Dr. B.R.AmbedkarMarathwada University, Aurangabad (1985), Biochemist at Kalawati Saran Children Hospital, Leady Harding medical collage GOI New Delhi and Assistant Technical Advisor under M/O HRD, Department WCD GOI. Due to my expertise in Fluoride research, I am part of the ICMR Task Force Group and presently dealing the ICMR Task force project“prevalence of fluorosis in the community of selected districts of India and development of an appropriate intervention model for prevention and control of fluorosis”.Member of expert committee and Trainer on national programme of prevalence and control of fluorosis, M/O Health and Family Welfare GOI. Elected as the President of International Society for fluoride research. The most significant findings with crucial public health significance have been 1) ameliorative effect of tamarind. 2) ameliorative effect oftamarind fruit extract supplementation on glucose intolerance and insulin resistance induced by fluoride.Member of Indian delegation to attend the 11th session of Codex Committee on contaminants in Foods at Rio De Janeiro, Brazil. In addition to fluoride research I involved in studies on Neurolathyrism and developed kid as animal model for Neurolathyrism studies. Have been successfully attracted research grants from UNICEF, FSSAI and ICMR. Recognised guide in Biochemistry and nutrition for Ph.D students under Osmania University.

Total number of publications in international and national peer reviewed journals till date : 40
  1. Arjun L Khandare,VakdeviValidandi , Naveen Boiroju. Fluoride alters serum elemental (Calcium, Magnesium, Copper and Zinc) homeostasis along with erythrocyte carbonic anhydrase activity in fluorosis endemic villages and restores on supply of safe drinking water in school going children of Nalgonda district, India. Biological Trace Element Research. https://doi.org/10.1007/s12011-018-1271-8.
  2. Arjun Lakshman Khandare . Vakdevi Validandi . Ananthan Rajendran . Toteja Gurudayal Singh . Longvah Thingnganing . Srinivasu Kurella .Raju Nagaraju . Srinivas Dheeravath . Nagaraju Vaddi . Srinivasulu Kommu .Yadaiah Maddela Health risk assessment of heavy metals and Strontium in groundwater used for drinking and cooking in 58 villages of Prakasam district, Andhra Pradesh, India Environ Geochem Health https://doi.org/10.1007/s10653-020-00596-1.
  3. Arjun L. Khandare, B. Kalakumar, Vakdevi Validandi, Qadri SSYH, N. Harishankar, Surya S. Singh, Venkaiah Kodali; Neurolathyrism in goat (Capra hircus) kid: Model development; Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2020.05.019
  4. R. Hari Kumar, Arjun Khandare, A. Laxmaiah, I. Meshram, N. Arlappa, VakdeviValidandi, K. Venkaiah, P. AmruthaRao, P. V. Sunu, V. Bhaskar& G. S.Toteja. Prolonged consumption of grass pea (64 g/Cu/day) along with millets And other cereals causes no Neurolathyrism. https://doi.org/10.1080/1028415X.2019.1642641
  5. Ashwini V. Izankar, Aniket P. Sarkate, Pramod S. Patil, Arjun L. Khandare, S. N. Sinha, Kshipra S. Karnik, Yogesh W. More and Dattatraya N. Pansare Simple chromium catalyzed oxidative synthesis of quinazolinones and Benzoxazinones from 2-aminobenzamide and anthranilic acid with arylaldehydes. Eur. Chem. Bull., 2019, 8(6)  180-187
  6. Ishwari A. Kale, Nileema S.Gore, Aniket P.Sarkate, Bhagwan K.Sakhale, Arjun L.Khandare, S.N.Sinha, Kshipra S. Karnik, Dattatraya N. Pansare Peel Extract associated oxidative green dakin synthesis of some phenols using aqueous banana extract catalyst Eur. Chem. Bull. 2019,8(5), 160-163
  7. VakdeviValidandi, Gopalan Viswanathan and Arjun L Khandare Comparison of Fluoride Levels (Total and Extracted) in Young, Old Tea Leaves and Market Tea Samples along with Impact of Tea Infusion on Dental Fluorosis in Fluoride Endemic Villages of Nalgonda District, India, Adv Dent & Oral Health 10(4): ADOH.MS.ID.555793 (2019)
  8. Munikumar Manne, Vakdevi Validandi, Arjun L Khandare, Reduction of fluoride toxicity by tamarind components: an in silicostudy. Fluoride 51(2)122–136 April-June 2018.
  9. Arjun L Khandare, VakdeviValidandi,MunikumarManne, G Bhanuprakash Reddy,Uday Kumar Putcha,Shankar RaoGourineni,BalakrishnaNagalla .  Tamarind fruit extract ameliorates fluoride toxicity by up regulating carbonic anhydrase ii: mechanistic study.Fluoride 51(2)137–152 , April-June 2018.
  10. Arjun L KhandareR. Hari Kumar2, II. Meshram, N. Arlappa, A. Laxmaiah, K.Venkaiah, P. AmruthaRao, VakdeviValidandiG.S. Toteja, Current Scenario of    consumption of Lathyrussativus 1 and lathyrism in three districts of  Chhattisgarh State, India.  TOXCON. 150 (2018)228-234.
  11. Munikumar Manne, Vakdevi Validandi, Arjun L Khandare.Tamarind components reduces fluoride toxicity: in silico study.  Fluoride 51(2)122–136 April-June 2018
  12. Arjun L Khandare, VakdeviValidandi, GopalanViswanathan, G Shankar Rao and N Balakrishna. Role of Carbonic Anhydrase and Triiodothyronine in Dental Caries Affected Children in Fluorosis Endemic Areas. Adv Dent & Oral Health 7(5) : ADOH.MS.ID.555721 (2018).
  13. Arjun L Khandare, VakdeviValidandi, Shankar RaoGourineni, ViswanathanGopalan, BalakrishnaNagalla.Dose dependent effect of fluoride on clinical and subclinical indices of fluorosis in school going children and its mitigation by supply of safe drinking water for 5 years: An Indian Study. Environ Monit Assess (2017) 189:579
  14. VakdeviValidandi, Shankar RaoGourineni, SrinivasDheeravath, BalakrishnaNagalla.Arjun L KhandareaTamarind supplementation ameliorates fluoride-induced glucose intolerance and insulin resistance in rats. Fluoride July-September 2017 50(3)314–323.
  15. Arjun L Khandarea    Report on XXXIIIrd conference of the International society for fluoride research,      during  November 9-11,2016 at NIN Hyderabad. Fluoride 49(4):467-470.
  16. Arjun L. Khandare& Shankar RaoGourineni&VakdeviValidandi Dental fluorosis, nutritional status, kidney damage,and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir, India. Environ Monit Assess (2017) 189:579.
  17. A.L. Khandare , J.J. Babu2, M. Ankulu, N. Aparna, AmolShirfule& G.S. Rao. Authors’ response Indian J Med Res 141, January 2015, pp 128.
  18. ALKhandare, VakdeviValidandi, ShankerRao,BalakrishnaNagallab.Effects of strontium and fluoride on bone mechanical and biochemical indices in guinea pigs.Fluoride 48(2)i-ii April-June 2015.
  19. AL Khandare, VakdeviValidandi, ShankerRao,BalakrishnaNagallab Synergistic effects of strontium and fluoride on nutritional status in guinea pigs (caviaporcellus) FLUORIDE  48(4)283-292 [Impact Factor: 0.9]
  20. AL Khandare, VakdeviValidandi, ShankerRao,BalakrishnaNagallab.Effects of strontium and fluoride on bone mechanical and biochemical indices in guinea pigs.Fluoride 48(2)i-ii April-June 2015.
  21. Arjun L. Khandare, JJ Babu, M. Ankul, N. Aparana, Amolshrifule& G. Shankar Rao. Grass pea consumption & present scenario of Neurolathyrism in Maharashtra State of India, Indian Council of Medical Research 140, July 2014 pp 96-101.
  22. Ankulu M, Aparna.N , RajuNaikVankudavathb, Arjun. L. KhandarePutative ligand-target docking studies of human AMPA selective Ionotropic glutamate receptors reveal that β-ODAP has high binding affinity compared to Tyrosine and glutamate.  International Research journal of Biochemistry and Bioinformatics vol3 (8) pp.130-139 oct.2013.
  23. Amol L Shirfule, VenkateshRacharla, SSYH Qadri and Arjun L Khandare. Exploring Antiurolithic Effects of GokshuradiPolyherbalAyurvedic Formulation in Ethylene Glycol Induced Urolithic Rats, Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 763720, 9 pages http://dx.doi.org/10.1155/2013/763720.
  24. Priyanka Shankar, SudipGhosh, K. Bhaskarachary, K. Venkaiah and Arjun L. Khandare Amelioration of chronic fluoride toxicity by calcium and fluoride free  water in rats: British Journal of Nutrition (2013), 110, 95–104.
  25. Arjun L. Khandare, M.Ankulu, N. Aparana.Role of glutamate and nitric oxide in onset of motor neuron degeneration in Neurolathyrism   Neuro Toxicology Volume 34, January 2013, Pages 269–274.
  26. Arjun L. Khandare;UdayKumar;Priyanka Shankar, ShankerRao  Copper Ameliorates Fluoride Toxicity in Fluoride and Molybdenum Fed Rabbits . Bio medical and environmental Sciences 2013;26(4):226-229.
  27. Arjun L   Khandare, Uday Kumar, ShankerRao. Magnesium hydroxide for protection against fluoride toxicity in rabbits. Fluoride 2011: 44(1) 12-17. Impact Factor: 1.6
  28. Arjun L Khandare, KomalRasaputra, IndrapalMesharam, ShankerRao. Effects of Smoking, use of Aluminium utensils, and Tamarind consumption on Fluorosis in a fluorotic village in Andhra Pradesh, India Fluoride 2010: 43(2)128-133.
  29. Arjun L Khandare, P Uday Kumar, N Hari Shankar, S Kalyanasundaram, G Shanker Rao. Effect of calcium deficiency induced by fluoride intoxication on lipid metabolism in rabbits Fluoride 2007: 40 ;184—189.
  30. Arjun L. Khandare, Rao GS, N. Balakrishan. Dual energy X-ray absorptionemetry (DXA) study of endemic skeletal fluorosis in village of Nalgonda district, Andhra Pradesh, India, Fluoride 2007: 40 ;190-197.
  31. Singotamu, A.L. Khandare, P. Madhusudhanachary. Scanning electron microscope studies on the effect of copper and molybdenum on the development of skeletal fluorosis in rabbits., Scaning 2006, 28:126-127.
  32. Arjun L. Khandare, R. Harikumar, B. Sivakumar. Severe bone deformities in young children coupled with vitamin D deficiency in fluoride affected villages, Bihar, India” Calcified Tissue International, 2005:76:418.
  33. L.Khandare, P. Suresh , P. Uday Kumar, N. Lakshmaiah, N. Manjula, G. Shanker Rao. Beneficial effect of copper supplementation on deposition of fluoride in bone in fluoride and Calcified Tissue International (2005)77:233-238.
  34. Arjun L Khandare, Uday Kumar P. Rao G. Shanker ,K. Venkaiah and N. Lakshmaiah. Additional beneficial effect of tamarind ingestion over defluoridated water supply to adolescent boys in a fluorotic areas. NUTRITION (2004):20:433-436.
  35. Bhargavi, Arjun L. Khandare, Venkaiah and G. Sarojani. Mineral content of water and food in fluorotic villages and prevalence of dental fluorosis.V. Biological Trace element Research(2004) :100; 195-203.
  36. Bhanuprakesh Reddy, Arjun L. Khandare, P. Yadagiri Reddy, G ShankerRao, N. Balakrishna and I.Srivalli. Antioxidant defense system and lipid per oxidation in patents with skeletal fluorosis and in fluoride-intoxicated rabbits. Toxicological sciences (2003)72:363-368.
  37. Khandare, GS Rao and N. Lakshmaiah. Effect of tamarind ingestion on fluoride excretion in humans.. Europian Journal of Clinical Nutrition (2002) 56:82-85.
  38. Arjun L.Khandare.P. Uday Kumar, NakkaLakahmaiah. Beneficial effect of tamarind ingestion on fluoride toxicity in dogs. Fluoride (2000):33-38.
  39. Arjun L. Khandare, Baburao S.Somavanshi and NakkaLakshmaiah. Purification and properties of pigeon kidney arginase. Indian Journal of Biophysics & Biochemistry(2000):37; 198-200.
  40. Vitamin K For the Newborn-Old avenues Revisited Indra Narayanan A. Salli and L. Khandare. Indian Pediatrics (1989):26;1229-34.


Papers published in Non-Peer reviewed journals
  1. Role of drinking water with high Silica and Strontium in Chronic Kidney Disease: An Exploratory Community-based Study in an Indian VillageIndian journal of community health / vol 27 / issue no 01 / jan – mar 2015,Arjun L Khandare, YathapuSrinivasa Reddy, NagallaBalakrishna, Gourineni Shankar Rao, TaduriGangadhar, NimmathotaArlappa.
  2. Effect of high dose fluoride administration on brain antioxidant enzymes and bone parameters in aging rats, Arjun Khandare, UdayKumar,ShankerRao, Rima Devi, Tulja and YathapuSrinivasa Reddy. International J. of Current Research and academic Review Vol.1(3) 2013
  3. Ankulu Ma, Aparna.Na ,RajuNaikVankudavathb, L. Khandare Putative ligand-target docking studies of human AMPA selective Ionotropic glutamate receptors reveal that β-ODAP has high binding affinity compared to Tyrosine and glutamate. * International Research journal of Biochemistry and Bioinformatics vol3 (8) pp.130-139 oct.2013
  4. Diet and nutrition status of four tribal blocks of Thane district of Maharashtra,India L. Khandare, V. Siruguri, A. Rao, K.Venkaiah , G. Reddy,G.S. Rao, Pakistan J of Nutr7(3)485-489, 2008.
  5. Assessment of current status of fluorosis in North-western Districts of Taml Nadu using Community index for Dental Fluorosis Harikumar, AL. KhandareetalJ. Hum. Ecology 21(1):27-32 (2007).
  6. Uptake of fluoride, aluminum and molybdenum by some vegetables from irrigation water, Arjun L. Khandare and G. ShankerRao. Hum. Ecology  19(4):283-288 (2006).
Papers published in proceedings
  1. Mitigation of fluorosis in Nalgonda district villages. AS.Narayana, Arjun L. Khandare.(2004) 4th International Workshop on Fluorosis prevention and defluorodation of water, 2nd –6th March 2004 at Sri Lanka, ( in workshop proceedings)
  2. Exploratory study on fluorosis in five districts of Tamil Nadu State. Arjun L. Khandare,R. Hari Kumar, K. Venkaiah, Gal reddyCh and B. Sivakumar National workshop on Nutritional effects on fluorosis( in workshop proceedings ) 19-20th 2004, at Chennai., India
  3. Vitamin-D deficiency in fluorosis affected village in Nawada district of Bihar. R. Harikumar, Arjun L. Khandare,B. Sivakumar. International workshop on medical geology 3-4, Febriary,2004, at Nagpur, India. Full Paper Published in Special publication No.83, Geological Survey of India. Page177-187.
Popular article
  1. Fluoride Toxicity-Dietary Intervention. Arjun L. Khandare,P. Uday Kumar and N. Lakshmaiah. Nutrition News 22(1) 2001.
  2. International Conference on Recent Trends in Lathyrussativus”  On 8 & 9 November, 2012 Report . CCDN (Cassava Cyanides &Neurolatyrism Network News) Issue 20: December 2012.
Awards and Honours
  1. Awarded CSIR fellowship for Ph.D.

  2. Elected as the president of International society for fluoride research.
  3. Received grants from ICMR to attend the International conference fluorosis at Sorrento, Italy and  Chiang Mai. Thailand. Chaired the session at Chiang Mai.Conferance.

  4. Organizing secretory of international conference on Fluorosis organized at NIN in 2016.

  5. Awarded the young scientist senior award in experimental nutrition at 48th National Conference of NSI held at St. John’s Research Institute Bangalore for the paper presented on Tamarind ameliorates the fluoride induced glucose intolerance & insulin resistance in rat I am the corresponding author.
  6. My Ph.D student ( Priyanka Shankar) thesis entitled “Effect of high fluoride and low calcium on bone metabolism in rats” received an award of the young scientist Junior award in experimentsl nutrition at 44th national Conference of the NSI held at Sri Venkateswara University, Tirupati. MsPrinka also received Ramanathan Prize in the 44th national conference of  NSI held at Sri Venkateswara University, Tirupatifor the paper “Amelioration of adverse effects of fluoride toxicity on calcium homioststis in low calcium treated rats.