The research activities and programs of the Department focus on various aspects of nutrition,
including the evaluation of nutrient deficiencies, the impact of nutrition on chronic age-related
diseases, and the formulation of dietary intervention strategies. We aim to unravel the
micronutrient-mediated molecular mechanisms related to age-related conditions, such as chronic
degenerative and metabolic disorders, including obesity and diabetes and their complications.
Our multidisciplinary approach incorporates clinical studies, animal models, and cell lines with
biochemical and molecular investigations to explore the links between diet, nutrient deficiencies,
and chronic diseases. Key areas of emphasis include micronutrient deficiencies and the role of
micronutrients and functional foods in mitigating chronic non-communicable diseases. We also
assess dietary intake patterns and their implications for health. Studies revealed the role of
micronutrients in the development of diabetic complications and neurodegenerative conditions.
Studies also show the importance of maternal protein restriction in terms of quality and quantity on
the normal development and growth of off-spring as well as the development of metabolic
derailments in later life.
A significant portion of our research examines protein modifications caused by non-enzymatic
glycation and aldo-keto reductases in chronic hyperglycemia. This work has led to the discovery of
novel bioactive molecules from functional foods and the development of formulations targeting
diabetes and obesity complications. Additionally, we investigate the role of protein quality control
mechanisms, including protein aggregation, ER stress, the ubiquitin-proteasome system,
autophagy, and small heat shock proteins in age-related diseases. We also explore how dietary and
nutritional interventions can modulate these protein quality control systems.
