Drug Safety

The division in its original form as a centre is established by ICMR in 1976 to conduct pharmacokinetics, pharmacodynamics for indigenization of dosages in nourished and under-nourished Indian population for various formulations. The major achievements include : i) Generated evidence based information on pharmacokinetics and pharmacodynamic activities of drugs for the first time in under-nourished Indian population, ii) Evaluated preventive and therapeutic potential of spices and condiments (turmeric, curcumin, ginger) for anti-mutagenic, carcinogenic, genotoxic, inflammatory and anti-oxidant, iii) Identified the gaps between precepts and practices on drug usage through studies on rational use of drugs, socio drug epidemiology etc., and developed intervention tools to promote rational use of drugs, iv) Only Centre in India generated the data on heavy metal toxicity specially Lead in various targeted population in India, v) The non clinical safety investigations of recombinants, DNA based vaccines and Genetically Modified Organism (GMO’s) supported in developing the regulatory guidelines in India apart from facilitating to translate the product for human use, vi) Taskforce Programs like Iron filing in tea has provided the scientific evidence to Food Safety Standards Authority of India (FSSAI) for policy decisions.

In addition, the division is gearing up to investigate the unresolved nutrigenomics phenomenon in the population. For example, the inter individual variations in micronutrient absorption and micronutrient toxicity may vary with genetic contexts. The overarching goal is to generate scientific data that inform the nutrient requirements and tolerable upper intakes limits (TUL) for a healthy wellbeing.


  1. Dr. Raghu Pullakhandam Scientist ‘E’ & HOD
  2. Dr. Shobi Veleri, Scientist ‘E’
  3. Dr. A. Rajanna, Scientist - D
  4. Dr. Palika Ravindranadh, Scientist - B
  5. Dr. Shashibhushan Kumar, TO
  6. Mr. Samyukta Kumar Reddy, TO