Dr. Suresh Challa is a distinguished biochemist specializing in Nutritional Biochemistry and Molecular Toxicology. He earned his Master’s degree in Biochemistry (Gold Medalist) and Ph.D. in Biochemical Toxicology from Sri Venkateswara University, Tirupati, in 1993 and 2003, respectively. In 2020, he was awarded a Doctor of Science (D.Sc.) in Biotechnology by Berhampur University. Dr. Suresh’s research focuses on molecular mechanisms underlying the cross-talk between mitochondria, lysosomes, and endoplasmic reticulum stress in brain function and neuroprotection. His laboratory investigates the protective effects of bioactive compounds against lead (Pb)-induced and Aβ-associated neurotoxicity, with direct implications for Alzheimer’s disease and other neurodegenerative disorders. He has successfully led multiple extramural research projects funded by DST, DBT, ICMR, and DHR and has significantly contributed to addressing critical public health concerns, including osteoporosis and Alzheimer’s disease. His pioneering work has been widely published in reputed scientific journals. Dr. Suresh has received several prestigious fellowships, including the NIH Visiting Scientist Fellowship (USA) twice (2004–2005 and 2010–2012), where he conducted advanced research on lead toxicity and its role in Alzheimer’s disease progression. He was also awarded the ICMR Young Biomedical Scientist Fellowship (2014–2015). He is an elected Fellow of the Royal Society of Biology (FRSB), UK, Fellow of the Association of Biotechnology and Pharmacy (FABP), and Fellow of the Telangana Academy of Sciences (FTAS). Actively involved in the scientific community, he serves on various national committees and advisory boards. Dr. Suresh is a Professor at the Academy of Scientific and Innovative Research (AcSIR) and AcSIR Coordinator of M.Sc. and Ph.D. programs at ICMR-NIN. As an accomplished mentor, he has supervised 11 Ph.D. scholars to completion, with four researchers currently working in his lab. Beyond his research and academic contributions, Dr. Suresh is a certified GLP inspector for NGCMS (DST, Govt. of India) and a CCSEA nominee for animal ethics committees under the Ministry of Animal Husbandry, Govt. of India. He actively collaborates with biotechnology and CRO companies on regulatory and ethical aspects of biomedical research.

1. Shrabani Das, Lokesh Murumulla, Pritha Ghosh, Suresh Challa. 2025. Heavy metal- induced disruption of the autophagy-lysosomal pathway: implications for aging and neurodegenerative disorders. Bimetals (Springer Nature). https://doi.org/10.1007/s10534-025-00665-x IF: 4.2
2. Lokesh Murumulla, Suresh Challa. 2024. Role of Apoptosis in Neurodegeneration: Therapeutic Targets and Strategies Pages 231-249, published in the book Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential, Springer Singapore, Edts Kuladip Jana; https://doi.org/10.1007/978-981-97-7905-5
3. Murumulla Lokesh, Lakshmi Jaya Madhuri Bandaru, Ajumeera Rajanna, Virendra Singh Dhayal and Suresh Challa. 2024. M1 polarization induction by lead and amyloid peptides in microglial cells: Implications for neurodegeneration process. Environmental Toxicology (Wiley);1–11; DOI: 10.1002/tox.24305; IF.4.7
4. Murumulla Lokesh, Lakshmi Jaya Madhuri Bandaru, Ajumeera Rajanna, J. Sreenivasa Rao and Suresh Challa. 2023. Unveiling Potential Neurotoxic Mechansisms: Pb‑Induced Activation of CDK5‑p25 Signaling Axis in Alzheimer’s Disease Development, Emphasizing CDK5 Inhibition and Formation of Toxic p25 Species. Molecular Neurobiology. (Springer Nature) https://doi.org/10.1007/s12035-023- 03783-0; IF.5.7
5. Mahesh Kumar, Giridhar Goudar, Paras Sharma, Rajesh Vishwakarma, Pallabika Gogoi, Anwesha Mahajan, Anilkumar Chandragiri, Subhash Kalpuri, J. J. Babu Geddam, Challa Suresh, Madhusudhana Chary, G. Venketrajireddy, M. S. Radhika, P. Sreenu & B. Tulja. 2023.Differentiating the nutrient composition, in-vitro starch digestibility, individual polyphenols and anti-oxidant properties of raw and popped makhana (Euryale ferox). Journal of Food Measurement and Characterization. (Springer Nature) https://doi.org/10.1007/s11694-023-02074-5
6. Lokesh Murumulla,Lakshmi Jaya Madhuri Bandaru and Suresh Challa. 2023. Heavy Metal Mediated Progressive Degeneration and Its Noxious Effects on Brain Microenvironment. Biological Trace Element Research;https://doi.org/10.1007/s12011-023-03778-x
7. Naresh Kumar Venna, Hauhnar Lalhruaitluanga, and Suresh Challa Cowpea isoflavones enhance the osteoblast differentiation and antioxidant capacity in synergy with vitamin D and β-carotene: A mechanistic in vitro study. Nutrition and Health. DOI: 10.1177/0260106023118160.
8. Lakshmi Jaya Madhuri Bandaru, Lokesh Murumulla, Bindu Lasya C, Krishna Prasad D, Suresh Challa. 2023.Exposure of combination of environmental pollutant, lead (Pb) and β‑amyloid peptides causes mitochondrial dysfunction and oxidative stress in human neuronal cells. Journal of Bioenergetics and Biomembranes. Springer https://doi.org/10.1007/s10863-023-09956-9. IF 3.853
9. Rajanna Ajumeera , Ganapathi Thipparapu, Barath Singh Padya, Lalitha Tirumala and Suresh Challa. 2022. Anti-cancer activity of pyridoxal phosphate and metformin combination in human pancreatic cancer cells. Nutrition and Health. DOI: 10.1177/02601060221137624
10. Lakshmi Jaya Madhuri B, Neelima Ayyalasomayajula, Lokesh Murumulla, Prasanna Kumar Dixit and Challa Suresh. 2022. Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and parkin in Pb and β-amyloid peptide induced toxicity. Toxicology Mechanisms and Methods. https://doi.org/10.1080/15376516.2022.2054749; IF 2.987
11. Babu R. M. Ray, T. Bala Narasaiah and Challa Suresh. 2022; Optimization of raw jack fruit fries and its physicochemical and sensory properties. Journal of Postharvest Technology.10(1): 35-51.
12. Ramakrishna Ungarala, Manne Munikumar, Sukesh Narayan Sinha, Dileshwar Kumar, R. Shyam Sunder and Suresh Challa; 2022; Assessment of Antioxidant, Immunomodulatory Activity of Oxidised Epigallocatechin-3-Gallate (Green Tea Polyphenol) and Its Action on the Main Protease of SARS-CoV-2—An In Vitro and In Silico Approach. Antioxidants, 11, 294. https://doi.org/10.3390/antiox11020294; IF 6.313.
13. Lakshmi Jaya Madhuri B, Neelima Ayyalasomayajula, Murumulla Lokesh and Suresh Challa; 2022; Mechanisms associated with the dysregulation of mitochondrial function due to lead exposure and possible implications on the development of Alzheimer’s disease. Biometals; Springer Nature DOI : 10.1007/s10534-021-00360-7; IF 2.978
14. Babu R. M. Ray, T. Bala Narasaiah and Challa Suresh. 2021; Different Heat Processing Methods on Flour Yield, Nutritional Composition and Acceptability of Jack Seed Flour-based Low-fat Functional Breadsticks. Current Journal of Applied Science and Technology.  40(44): 1-15.
15. Neelima Ayyalasomayajula, Lakshmi Jaya Madhuri Bandaru, Prasanna K Dixit, Chetty S Chellu, Challa Suresh; 2021; Mitochondria mediated moderation of apoptosis in cytotoxic neuronal cells induced by Lead and Amyloid peptides. Biological Trace Element Research; Springer Nature; https://doi.org/10.1007/s12011-021-02959-w; IF 3.8
16. Babu R. M. Ray, Challa Suresh and T. Bala Narasaiah. 2021; Jackfruit Waste to Wealth - Confectionery Chews. Mysore J. Agric. Sci., 55 (4): 48-60.
17. Ayyalasomayajula Neelima, Madhuri Bandaru,Prasanna Kumar Dixit, Ajumeera Rajanna, Chellu Chetty S, Challa Suresh; ; 2020; Inactivation of GAP-43 due to the depletion of cellular calcium by the Pb and amyloid peptide induced toxicity: An in vitro approach; Chemico-Biological Interactions (Elsevier) 316; 109927; IF 5.12
18. Sujatha Thathapudi, Jaya shankar erukambattu, Uday kumar putcha, Surekha Mullapudi Venkata, Suresh Challa. 2019; Multifactor dimensionality reduction analysis for detecting SNP-SNP, SNP-environment interactions associated with polycystic ovarian syndrome among South Indian women; International Journal of Molecular Biology; 4(2) 59-65. CORRESPONDING AUTHOR
19. Rishika J, Rajanna A, Suresh C; 2022; Stimulation of osteoblastic differentiation by cowpea isoflavones via p38 MAPK- CBFA1/RUNX-2 pathway in MG-63 osteoblasts. Scientific Reports (Nature) (Accepted) IF: 4.525
20. Ayyalasomayajula Neelima, Ajumeera Rajanna, Chellu Chetty S, Challa Suresh; 2019 Mitigative effects of Epigallocatechin gallate in terms of diminishing apoptosis and oxidative stress generated by the combination of lead and amyloid peptides in human neuronal cells; Journal of Biochemical and Molecular Toxicology  Wiley; DOI: 10.1002/jbt.22393, 2019; IF: 2.965
21. Rishika Jadai, Naresh Venna, Rajanna Ajumeera and Suresh Challa; 2019; Isoflavones rich cowpea and vitamin D induces the proliferation and differentiation of human osteoblasts via BMP-2/Smad pathway activation: Mechanistic approach; IUBMB Life (Wiley) 1-12, DOI: 10.1002/iub.2127. IF: 3.885
22. Challa Suresh and Prasanna K Dixit Antioxidant and Antiapoptotic Effects of Fraxetin against Lead Induced Toxicity in Human Neuroblastoma Cells. Organic & Medicinal Chem IJ 5(1): 001-005, 2018; DOI: 10.19080/OMCIJ.2018.04.555651
23. Challa Suresh, Ajumeera Rajanna and Venna Naresh.2018 Phytoestrogens as a natural source for the possible colon cancer treatment, pages 259-281 published in a book Springer Nature Singapore Pte Ltd.  S. Akhtar, M. K. Swamy (eds.), Anticancer Plants: Mechanisms and Molecular Interactions. https://doi.org/10.1007/978-981-10-8417-1_11
24. Rajanna Ajumeera, Ganapathi Thipparapu, and Suresh Challa 2018. Remedy of Targeting Cancer and Cancer. Pages 289-320; Published in Springer Nature Singapore Pte Ltd. M. S. Akhtar, M. K. Swamy (eds.), Anticancer Plants: Natural Products and Biotechnological Implements, https://doi.org/10.1007/978-981-10-8064-7_13
25. Ayyalasomayajula Neelima, Ajumeera Rajanna , Reddy G. Bhanuprakash , C.S. Chetty , Challa Suresh Deleterious effects of combination of lead and β-amyloid peptides in inducing apoptosis and altering cell cycle in human neuroblastoma cells. Interdiscip Toxicol. 2017; Vol. 10(3): 101–106.  doi: 10.1515/intox-2017-0015
26. Neelima Ayyalasomyajula and Challa Suresh. 2017. Mechanistic comparison of current pharmacological treatments and novel phytochemicals to target amyloid peptides in Alzheimer's and neurodegenerative diseases. Nutritional Neuroscience. DOI 10.1080/1028415X.2017.1345425 IF: 5.00
27. Challa Suresh and Prasanna Kumar Dixit.2017. Ameliorating effects of Magnolol in reducing the toxicity induced by Heavy metal Lead in the human brain cells. Journal of Pharmacology and Toxicology, 12(2), pp 111-119
28. Suresh C and Dixit PK. 2016. Mitigative Effects of Koenidine in reducing the toxicity induced by heavy metal Lead in Human neuroblastoma cells. Journal of Chemical Biology and Therapeutics. 2016, 1:2: 1000113
29. Rishika J, Vijayalakshmi V, Rajanna A, Naresh V and Suresh C 2016. Possible synergistic role of Cowpea Isoflavones and Vitamin D combo in the bone formation of MG-63 osteoblasts. Vitamins and Minerals. 5:3 DOI: 10.4172/2376-1318.1000146
30. Sumangala Rao and C. Suresh 2015. Analysis of genetic differentiation of few edible Cassia species using RAPD molecular markers. International Journal of Pharmacy and Pharmaceutical Research, 3(2); 58-65
31. S.N.Jyothi, M.Shailaja, Jyotsna Viveni, C.Suresh. 2014 . Identification of a Proteinaceous Alpha Amylase Inhibitor from a Medicinal Herb Oxalis Corniculata.L(Oxalidaceae) Journal of Homeopathy & Ayurvedic Medicine, 3(4),165-168. doi:10.4172/2167-1206.1000165.
32. S.N.Jyothi, P.Hemalatha, A.Avanthi and Suresh Challa.2013. A comparative analysis on the alpha amylase inhibitory potential of six ornamental medicinal plants. J. Nat. Prod. Plant Resour., 3 (3):1-6
33. Sumangala Rao and C. Suresh.2013. In vitro and In vivo Effects of the Leaf Extracts of Cassia tora and Cassia sophera in Reducing the Cytotoxicity and Angiogenesis. British Biotechnology Journal,3(3): 377-389.
34. Suresh and V. Vijayalakshmi. 2013. Protective effects of Phytoestrogens like Daidzein and Genistein against oxidative stress in the Caco-2 colon carcinoma cells. Abstract published in Annals of Nutrition and Metabolism, 1720.
35. Sumangala Rao, T Vijayadeepthi, Muhammad Zoheb and Challa Suresh. 2012. Evaluation of antioxidant and antimicrobial potential of two edible Cassia species to explore their Neutraceutical values. Journal of Pharmacy Research, 5(3) 1650-1655.
36. Challa Suresh, Johnny Johnson, Roshini Mohan and Chellu S. Chetty. 2012. Synergistic effects of amyloid peptides and lead on human  neuroblastoma cells. Cellular and Molecular Biology Letters, 17(3) 408-421.
37. Suresh Challa, Hua Zhao, Angelique Gumbs, Chellu S. Chetty and Himangshu S. Bose. 2012. New ionic derivatives of betulinic acid as highly potent anti-cancer agents. Bioorganic & Medicinal Chemistry Letters (22) 1734-1738. IF 2.823
38. Sasidhar Pasumarthi, Murali Krishna Chimata, Chellu S Chetty, Suresh Challa. 2011 Screening of Phytochemical Compounds in selected Medicinal Plants of Deccan Plateau and their viability effects on Caco-2 Cells. Journal of Medicinal Plant Research 5(32) 6955-6962.
39. Murali Krishna Chimata, Chellu S Chetty, and Challa Suresh. 2011 Fermentative production and thermo stability characterization of alpha amylase from Aspergillus species and its application potential evaluation in desizing of cotton cloth. Biotechnology Research International, 1-8 (doi:10.4061/2011/323891)
40. Hua Zhao, Shaletha Holmes, Gary A. Baker, Suresh Challa, Himangshu S. Bose, and Zhiyan Song.2011 Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors Journal of Enzyme Inhibition and Medicinal Chemistry, 1-11
41. Challa Suresh, Johnny Johnson, Mary C Wyatt and Chellu S Chetty. 2011. Influence of Environmental Phytoestrogens in Nutrition and Health published in a book " Environmental Pollution, Ecology and Human Health ",  NAROSA publication, Eds:  Gottipolu RR et al. 97-108.
42. S.N.Jyothi, P.Hemalatha, Suresh Challa. 2011. Evaluation of alpha amylase inhibitory potential of three medicinally important traditional wild food plants of India. International Journal of Green Pharmacy, 5(2), 95-99
43. Challa Suresh, Johnny Johnson, Tracey M. Modeste and Chellu S. Chetty. 2011. Protective role of epigallocatechin 3-gallate against lead-induced toxicity in human neuroblastoma cells. Toxicological & Environmental Chemistry, 93(5),1018–1027. IF 1.437
44. Padmaja R. Jonnalagadda*, A. Y. E. Prasad, Katla Ashok Reddy, Challa Suresh, M. Vishnu Vardhana Rao, Goparaju Ramya and D. Raghunatha Rao. 2010. Biochemical alterations of certain health parameters in cotton growing farmers exposed to organophosphorous and pyrethroid insecticides. African Journal of Biotechnology, 9(49), 8369-8377.
45. Murali Krishna Chimata, Sasidhar.P, Suresh Challa.2010. Production of Extracellular amylase from agricultural residues by a newly isolated Aspergillus species in Solid State Fermentation. African Journal of Biotechnology. 9(32), 5162-5169.
46. Murali Krishna Chimata, Sasidhar Pasumarthi, Suresh Challa. 2010. Optimization and production of extracellular amylase from newly isolated Aspergillus species by Submerged Fermentation. Current Trends in Biotechnology and Pharmacy. 4(3): 795-800.
47. Chennaiah, V. Vijayalakshmi and C. Suresh. 2010. Effect of the supplementation of dietary rich phytoestrogens in altering the vitamin D levels in diet induced osteoporotic rat model. Journal of Steroid Biochemistry and Molecular Biology.121:268–272. IF 3.775
48. Suresh. 2010. Phytoestrogens and their role as bio-resources in promoting health and curbing diseases. Book Chapter: Bioresources for Food Security and Rural Livelihood Pages 111-125, Narendra Publishing House, Eds GK Kulkarni and BN Pandey.
49. P.C.Nagajyoti, N.Dinakar, S.Suresh, Y.Udaykiran, C. Suresh, T.N.V.K.V. Prasad and T.Damodharam. 2009. Biomass Industrial Effluent Effect on Carbohydrates, Aminoacids, Nitrite and Nitrite Enzyme activities of Arachis hypogaea L. Agricultural Sciences in China (Elsevier), 8(2): 203-215.
50. Dinakar, P.C. Nagajyothi, S. Suresh, T. Damodharam and C. Suresh. 2009. Cadmium induced changes on Proline, Antioxidant Enzymes, Nitrate and Nitrite reductases in Arachis hypogaea. L. Journal of Environmental Biology, 30 (2), 289-294.
51. C. Nagajyothi, N. Dinakar, S. Suresh, Y. Udaykiran, C Suresh and T Damodharam. 2008. Effect of industrial effluent on the morphological parameters and chlorophyll content of green gram (Phaseolus aureus Roxb). Journal of Environmental Biology, 30 (3), 385-388.
52. Challa Suresh, Mohan C. Vemuri and Chellu S. Chetty. 2008. Effect of epigallocatechin 3-gallate in human neuroblastoma cells exposed to lead. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 148(4), 462-463. IF 3.228
53. Suresh, J.Padmaja, P. Uday Kumar, K. Divya, P. Sandesh, and P. Swadeep. 2008. Alterations In The Antioxidant Profile In Patients With Colorectal Carcinoma. Current Trends in Biotechnology and Pharmacy, 2 (4), 531 -537.
54. C. Nagajyoti, N. Dinakar, T.N.V.K.V. Prasad, C. Suresh and T. Damodharam. 2008. Heavy metal toxicity: Industrial Effluent Effect on Groundnut (Arachis hypogaea L.) Seedlings. Journal of Applied Sciences Research, 4(1), 110-121.
55. C. Nagajyothi, N. Dinakar, Y. Udaykiran, K.Prasad C Suresh and T. Damodharam. 2008. Effect of biomass power plant effluent on biochemical parameters of Arachis hypogaea L. Asian Journal of Chemistry, 20(7),  5489-5496.
56. Chellu S Chetty, Mohan C. Vemuri, Gottipolu R Reddy and Challa Suresh. 2007. Protective effect of 17--estradiol in Human Neurocellular models of Lead exposure. NeuroToxicology, 28, 396–401. IF 4.294
57. CS Chetty, MC Vemuri, K Campbell and C Suresh. Neurotoxic effects of Lead on human neuroblastoma in cell cultures. Abstract been published in The Toxicologist an official journal of Toxicological Sciences, 90 (1), 366.
58. Shiva Prakash, S. Chennaiah, YSR Murthy, E. Anjaiah and C. Suresh. 2006. Altered adenosine deaminase activity in type-2 diabetes mellitus. Journal, Indian Academy of Clinical Medicine, 7(2), 114-117.
59. Challa Suresh, Adanna O. Dennis, Josephine Heinz, Mohan C Vemuri, and C.S. Chetty. 2006. Melatonin Protection Against Lead Induced Changes in Human Neuroblastoma Cell Cultures. International Journal of Toxicology, 25(6), 459-464. IF 1.205
60. Chellu S. Chetty, Mohan C. Vemuri, Khamisi Campbell and Challa Suresh. 2005. Lead induced cell death of Human Neuroblastoma Cells involves GSH deprivation. Cellular and Molecular Biology Letters, 10, 413-423 IF 5.787.