Scientist ‘F' & HoD

Email: Contact:  +91-40-27197349

Brief Profile

Dr. Suresh Challa has obtained his Master’s Degree in Biochemistry from Sri Venkateswara University, Tirupati in the year 1993 and received Gold Medal for being the first rank holder in the university. He has obtained his Ph.D in Biochemical Toxicology from the same university. He is holding Scientist F and Senior Deputy Director position and Head of Cell Biology Department at ICMR-NIN and serving ICMR for more than 27 years. His labs research interests include Nutritional Biochemistry and Biochemical Toxicology in both in vivo and in vitro models. His present research involves in addressing the synergic toxic effects of Heavy metal Lead and amyloid peptides on Human brain cells and elucidating the various intracellular mechanisms on Alzheimer’s progression. Special focus is on the function of mitochondria and its cross talk with endoplasmic reticulum. Possible protection by different neuroprotective compounds is also been investigated. Second area is addressing the pathologies associated with Osteoporosis and different therapeutic approaches in combating the disease and studying the intracellular effects of Cowpea isoflavones using both in vitro and in vivo models. He has been recognized as PhD research supervisor at Osmania university, Nagarjuna University, NTR Health University and JNTU, Hyderabad in the subjects of Biochemistry, Biotechnology and Nutrition. Dr. Suresh has received NIH Visiting Scientist Fellowship from 2004-2005 (one year) and also during 2010-2012 (two years) and did his research at USA. He also obtained prestigious ICMR Young Bio-medical Scientist fellowship for the years 2014-2015. He is a Fellow of Association of Biotechnology and Pharmacy (FABP) and an active member of several scientific bodies. He is serving as Course-coordinator for M.Sc., in Applied Nutrition and M.Sc. Sports Nutrition and also serving as faculty at for various courses being conducted at ICMR-NIN. In addition, he is also serving as Board of studies member for various state and central universities. He is an expert in regulatory activities and serving as GLP inspector for NGCMA, Ministry of Science and Technology (DST), Govt of India.

Total publications: 51; Publications in the last 10 years
  1. Mahesh Kumar, Giridhar Goudar, Paras Sharma, Rajesh Vishwakarma, Pallabika Gogoi, Anwesha Mahajan, Anilkumar Chandragiri, Subhash Kalpuri, J. J. Babu Geddam, Challa Suresh, Madhusudhana Chary, G. Venketrajireddy, M. S. Radhika, P. Sreenu & B. Tulja. 2023.Differentiating the nutrient composition, in-vitro starch digestibility, individual polyphenols and anti-oxidant properties of raw and popped makhana (Euryale ferox). Journal of Food Measurement and Characterization. (Springer Nature)
  2. Lokesh Murumulla,Lakshmi Jaya Madhuri Bandaru and Suresh Challa. 2023. Heavy Metal Mediated Progressive Degeneration and Its Noxious Effects on Brain Microenvironment. Biological Trace Element Research;
  3. Naresh Kumar Venna, Hauhnar Lalhruaitluanga, and Suresh Challa Cowpea isoflavones enhance the osteoblast differentiation and antioxidant capacity in synergy with vitamin D and β-carotene: A mechanistic in vitro study. Nutrition and Health. DOI: 10.1177/0260106023118160.
  4. Lakshmi Jaya Madhuri Bandaru, Lokesh Murumulla, Bindu Lasya C, Krishna Prasad D, Suresh Challa. 2023.Exposure of combination of environmental pollutant, lead (Pb) and β‑amyloid peptides causes mitochondrial dysfunction and oxidative stress in human neuronal cells. Journal of Bioenergetics and Biomembranes. Springer IF 3.853
  5. Rajanna Ajumeera , Ganapathi Thipparapu, Barath Singh Padya, Lalitha Tirumala and Suresh Challa. 2022. Anti-cancer activity of pyridoxal phosphate and metformin combination in human pancreatic cancer cells. Nutrition and Health. DOI: 10.1177/02601060221137624
  6. Lakshmi Jaya Madhuri B, Neelima Ayyalasomayajula, Lokesh Murumulla, Prasanna Kumar Dixit and Challa Suresh. 2022. Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and parkin in Pb and β-amyloid peptide induced toxicity. Toxicology Mechanisms and Methods.; IF 2.987
  7. Babu R. M. Ray, T. Bala Narasaiah and Challa Suresh. 2022; Optimization of raw jack fruit fries and its physicochemical and sensory properties. Journal of Postharvest Technology.10(1): 35-51.
  8. Ramakrishna Ungarala, Manne Munikumar, Sukesh Narayan Sinha, Dileshwar Kumar, R. Shyam Sunder and Suresh Challa; 2022; Assessment of Antioxidant, Immunomodulatory Activity of Oxidised Epigallocatechin-3-Gallate (Green Tea Polyphenol) and Its Action on the Main Protease of SARS-CoV-2—An In Vitro and In Silico Approach. Antioxidants, 11, 294.; IF 6.313.
  9. Lakshmi Jaya Madhuri B, Neelima Ayyalasomayajula, Murumulla Lokesh and Suresh Challa; 2022; Mechanisms associated with the dysregulation of mitochondrial function due to lead exposure and possible implications on the development of Alzheimer’s disease. Biometals; Springer Nature DOI : 10.1007/s10534-021-00360-7; IF 2.978
  10. Babu R. M. Ray, T. Bala Narasaiah and Challa Suresh. 2021; Different Heat Processing Methods on Flour Yield, Nutritional Composition and Acceptability of Jack Seed Flour-based Low-fat Functional Breadsticks. Current Journal of Applied Science and Technology.  40(44): 1-15.
  11. Neelima Ayyalasomayajula, Lakshmi Jaya Madhuri Bandaru, Prasanna K Dixit, Chetty S Chellu, Challa Suresh; 2021; Mitochondria mediated moderation of apoptosis in cytotoxic neuronal cells induced by Lead and Amyloid peptides. Biological Trace Element Research; Springer Nature;; IF 3.8
  12. Babu R. M. Ray, Challa Suresh and T. Bala Narasaiah. 2021; Jackfruit Waste to Wealth - Confectionery Chews. Mysore J. Agric. Sci., 55 (4): 48-60.
  13. Ayyalasomayajula Neelima, Madhuri Bandaru,Prasanna Kumar Dixit, Ajumeera Rajanna, Chellu Chetty S, Challa Suresh; ; 2020; Inactivation of GAP-43 due to the depletion of cellular calcium by the Pb and amyloid peptide induced toxicity: An in vitro approach; Chemico-Biological Interactions (Elsevier) 316; 109927; IF 5.12
  14. Sujatha Thathapudi, Jaya shankar erukambattu, Uday kumar putcha, Surekha Mullapudi Venkata, Suresh Challa. 2019; Multifactor dimensionality reduction analysis for detecting SNP-SNP, SNP-environment interactions associated with polycystic ovarian syndrome among South Indian women; International Journal of Molecular Biology; 4(2) 59-65. CORRESPONDING AUTHOR
  15. Rishika J, Rajanna A, Suresh C; 2022; Stimulation of osteoblastic differentiation by cowpea isoflavones via p38 MAPK- CBFA1/RUNX-2 pathway in MG-63 osteoblasts. Scientific Reports (Nature) (Accepted) IF: 4.525
  16. Ayyalasomayajula Neelima, Ajumeera Rajanna, Chellu Chetty S, Challa Suresh; 2019 Mitigative effects of Epigallocatechin gallate in terms of diminishing apoptosis and oxidative stress generated by the combination of lead and amyloid peptides in human neuronal cells; Journal of Biochemical and Molecular Toxicology  Wiley; DOI: 10.1002/jbt.22393, 2019; IF: 2.965
  17. Rishika Jadai, Naresh Venna, Rajanna Ajumeera and Suresh Challa; 2019; Isoflavones rich cowpea and vitamin D induces the proliferation and differentiation of human osteoblasts via BMP-2/Smad pathway activation: Mechanistic approach; IUBMB Life (Wiley) 1-12, DOI: 10.1002/iub.2127. IF: 3.885
  18. Challa Suresh and Prasanna K Dixit Antioxidant and Antiapoptotic Effects of Fraxetin against Lead Induced Toxicity in Human Neuroblastoma Cells. Organic & Medicinal Chem IJ 5(1): 001-005, 2018; DOI: 10.19080/OMCIJ.2018.04.555651
  19. Challa Suresh, Ajumeera Rajanna and Venna Naresh.2018 Phytoestrogens as a natural source for the possible colon cancer treatment, pages 259-281 published in a book Springer Nature Singapore Pte Ltd.  S. Akhtar, M. K. Swamy (eds.), Anticancer Plants: Mechanisms and Molecular Interactions.
  20. Rajanna Ajumeera, Ganapathi Thipparapu, and Suresh Challa 2018. Remedy of Targeting Cancer and Cancer. Pages 289-320; Published in Springer Nature Singapore Pte Ltd. M. S. Akhtar, M. K. Swamy (eds.), Anticancer Plants: Natural Products and Biotechnological Implements,
  21. Ayyalasomayajula Neelima, Ajumeera Rajanna , Reddy G. Bhanuprakash , C.S. Chetty , Challa Suresh Deleterious effects of combination of lead and β-amyloid peptides in inducing apoptosis and altering cell cycle in human neuroblastoma cells. Interdiscip Toxicol. 2017; Vol. 10(3): 101–106.  doi: 10.1515/intox-2017-0015
  22. Neelima Ayyalasomyajula and Challa Suresh. 2017. Mechanistic comparison of current pharmacological treatments and novel phytochemicals to target amyloid peptides in Alzheimer's and neurodegenerative diseases. Nutritional Neuroscience. DOI 10.1080/1028415X.2017.1345425 IF: 5.00
  23. Challa Suresh and Prasanna Kumar Dixit.2017. Ameliorating effects of Magnolol in reducing the toxicity induced by Heavy metal Lead in the human brain cells. Journal of Pharmacology and Toxicology, 12(2), pp 111-119
  24. Suresh C and Dixit PK. 2016. Mitigative Effects of Koenidine in reducing the toxicity induced by heavy metal Lead in Human neuroblastoma cells. Journal of Chemical Biology and Therapeutics. 2016, 1:2: 1000113
  25. Rishika J, Vijayalakshmi V, Rajanna A, Naresh V and Suresh C 2016. Possible synergistic role of Cowpea Isoflavones and Vitamin D combo in the bone formation of MG-63 osteoblasts. Vitamins and Minerals. 5:3 DOI: 10.4172/2376-1318.1000146
  26. Sumangala Rao and C. Suresh 2015. Analysis of genetic differentiation of few edible Cassia species using RAPD molecular markers. International Journal of Pharmacy and Pharmaceutical Research, 3(2); 58-65
  27. S.N.Jyothi, M.Shailaja, Jyotsna Viveni, C.Suresh. 2014 . Identification of a Proteinaceous Alpha Amylase Inhibitor from a Medicinal Herb Oxalis Corniculata.L(Oxalidaceae) Journal of Homeopathy & Ayurvedic Medicine, 3(4),165-168. doi:10.4172/2167-1206.1000165.
  28. S.N.Jyothi, P.Hemalatha, A.Avanthi and Suresh Challa.2013. A comparative analysis on the alpha amylase inhibitory potential of six ornamental medicinal plants. J. Nat. Prod. Plant Resour., 3 (3):1-6
  29. Sumangala Rao and C. Suresh.2013. In vitro and In vivo Effects of the Leaf Extracts of Cassia tora and Cassia sophera in Reducing the Cytotoxicity and Angiogenesis. British Biotechnology Journal,3(3): 377-389.
  30. Suresh and V. Vijayalakshmi. 2013. Protective effects of Phytoestrogens like Daidzein and Genistein against oxidative stress in the Caco-2 colon carcinoma cells. Abstract published in Annals of Nutrition and Metabolism, 1720.
  31. Sumangala Rao, T Vijayadeepthi, Muhammad Zoheb and Challa Suresh. 2012. Evaluation of antioxidant and antimicrobial potential of two edible Cassia species to explore their Neutraceutical values. Journal of Pharmacy Research, 5(3) 1650-1655.
  32. Challa Suresh, Johnny Johnson, Roshini Mohan and Chellu S. Chetty. 2012. Synergistic effects of amyloid peptides and lead on human  neuroblastoma cells. Cellular and Molecular Biology Letters, 17(3) 408-421.
  33. Suresh Challa, Hua Zhao, Angelique Gumbs, Chellu S. Chetty and Himangshu S. Bose. 2012. New ionic derivatives of betulinic acid as highly potent anti-cancer agents. Bioorganic & Medicinal Chemistry Letters (22) 1734-1738. IF 2.823
  34. Sasidhar Pasumarthi, Murali Krishna Chimata, Chellu S Chetty, Suresh Challa. 2011 Screening of Phytochemical Compounds in selected Medicinal Plants of Deccan Plateau and their viability effects on Caco-2 Cells. Journal of Medicinal Plant Research 5(32) 6955-6962.
  35. Murali Krishna Chimata, Chellu S Chetty, and Challa Suresh. 2011 Fermentative production and thermo stability characterization of alpha amylase from Aspergillus species and its application potential evaluation in desizing of cotton cloth. Biotechnology Research International, 1-8 (doi:10.4061/2011/323891)
  36. Hua Zhao, Shaletha Holmes, Gary A. Baker, Suresh Challa, Himangshu S. Bose, and Zhiyan Song.2011 Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors Journal of Enzyme Inhibition and Medicinal Chemistry, 1-11
  37. Challa Suresh, Johnny Johnson, Mary C Wyatt and Chellu S Chetty. 2011. Influence of Environmental Phytoestrogens in Nutrition and Health published in a book " Environmental Pollution, Ecology and Human Health ",  NAROSA publication, Eds:  Gottipolu RR et al. 97-108.
  38. S.N.Jyothi, P.Hemalatha, Suresh Challa. 2011. Evaluation of alpha amylase inhibitory potential of three medicinally important traditional wild food plants of India. International Journal of Green Pharmacy, 5(2), 95-99
  39. Challa Suresh, Johnny Johnson, Tracey M. Modeste and Chellu S. Chetty. 2011. Protective role of epigallocatechin 3-gallate against lead-induced toxicity in human neuroblastoma cells. Toxicological & Environmental Chemistry, 93(5),1018–1027. IF 1.437
  40. Padmaja R. Jonnalagadda*, A. Y. E. Prasad, Katla Ashok Reddy, Challa Suresh, M. Vishnu Vardhana Rao, Goparaju Ramya and D. Raghunatha Rao. 2010. Biochemical alterations of certain health parameters in cotton growing farmers exposed to organophosphorous and pyrethroid insecticides. African Journal of Biotechnology, 9(49), 8369-8377.
  41. Murali Krishna Chimata, Sasidhar.P, Suresh Challa.2010. Production of Extracellular amylase from agricultural residues by a newly isolated Aspergillus species in Solid State Fermentation. African Journal of Biotechnology. 9(32), 5162-5169.
  42. Murali Krishna Chimata, Sasidhar Pasumarthi, Suresh Challa. 2010. Optimization and production of extracellular amylase from newly isolated Aspergillus species by Submerged Fermentation. Current Trends in Biotechnology and Pharmacy. 4(3): 795-800.
  43. Chennaiah, V. Vijayalakshmi and C. Suresh. 2010. Effect of the supplementation of dietary rich phytoestrogens in altering the vitamin D levels in diet induced osteoporotic rat model. Journal of Steroid Biochemistry and Molecular Biology.121:268–272. IF 3.775
  44. Suresh. 2010. Phytoestrogens and their role as bio-resources in promoting health and curbing diseases. Book Chapter: Bioresources for Food Security and Rural Livelihood Pages 111-125, Narendra Publishing House, Eds GK Kulkarni and BN Pandey.
  45. P.C.Nagajyoti, N.Dinakar, S.Suresh, Y.Udaykiran, C.Suresh, T.N.V.K.V. Prasad and T.Damodharam. 2009. Biomass Industrial Effluent Effect on Carbohydrates, Aminoacids, Nitrite and Nitrite Enzyme activities of Arachis hypogaea L. Agricultural Sciences in China (Elsevier), 8(2): 203-215.
  46. Dinakar, P.C. Nagajyothi, S. Suresh, T. Damodharam and C. Suresh. 2009. Cadmium induced changes on Proline, Antioxidant Enzymes, Nitrate and Nitrite reductases in Arachis hypogaea. L. Journal of Environmental Biology, 30 (2), 289-294.
  47. C. Nagajyothi, N. Dinakar, S. Suresh, Y. Udaykiran, C Suresh and T Damodharam. 2008. Effect of industrial effluent on the morphological parameters and chlorophyll content of green gram (Phaseolus aureus Roxb). Journal of Environmental Biology, 30 (3), 385-388.
  48. Challa Suresh, Mohan C. Vemuri and Chellu S. Chetty. 2008. Effect of epigallocatechin 3-gallate in human neuroblastoma cells exposed to lead. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 148(4), 462-463. IF 3.228
  49. Suresh, J.Padmaja, P. Uday Kumar, K. Divya, P. Sandesh, and P. Swadeep. 2008. Alterations In The Antioxidant Profile In Patients With Colorectal Carcinoma. Current Trends in Biotechnology and Pharmacy, 2 (4), 531 -537.
  50. C. Nagajyoti, N. Dinakar, T.N.V.K.V. Prasad, C. Suresh and T. Damodharam. 2008. Heavy metal toxicity: Industrial Effluent Effect on Groundnut (Arachis hypogaea L.) Seedlings. Journal of Applied Sciences Research, 4(1), 110-121.
  51. C. Nagajyothi, N. Dinakar, Y. Udaykiran, K.Prasad C Suresh and T. Damodharam. 2008. Effect of biomass power plant effluent on biochemical parameters of Arachis hypogaea L. Asian Journal of Chemistry, 20(7),  5489-5496.
  52. Chellu S Chetty, Mohan C. Vemuri, Gottipolu R Reddy and Challa Suresh. 2007. Protective effect of 17--estradiol in Human Neurocellular models of Lead exposure. NeuroToxicology, 28, 396–401. IF 4.294
  53. CS Chetty, MC Vemuri, K Campbell and C Suresh. Neurotoxic effects of Lead on human neuroblastoma in cell cultures. Abstract been published in The Toxicologist an official journal of Toxicological Sciences, 90 (1), 366.
  54. Shiva Prakash, S. Chennaiah, YSR Murthy, E. Anjaiah and C. Suresh. 2006. Altered adenosine deaminase activity in type-2 diabetes mellitus. Journal, Indian Academy of Clinical Medicine, 7(2), 114-117.
  55. Challa Suresh, Adanna O. Dennis, Josephine Heinz, Mohan C Vemuri, and C.S. Chetty. 2006. Melatonin Protection Against Lead Induced Changes in Human Neuroblastoma Cell Cultures. International Journal of Toxicology, 25(6), 459-464. IF 1.205
  56. Chellu S. Chetty, Mohan C. Vemuri, Khamisi Campbell and Challa Suresh. 2005. Lead induced cell death of Human Neuroblastoma Cells involves GSH deprivation. Cellular and Molecular Biology Letters, 10, 413-423 IF 5.787.
Total number of books and book chapters: 2; List of books and book chapters last 10 years
  1. C. Suresh. 2010. Phytoestrogens and their role as bio-resources in promoting health and curbing diseases. Book Chapter: Bioresources for Food Security and Rural Livelihood Pages 111-125, Narendra Publishing House, Eds GK Kulkarni and BN Pandey.
  2. Challa Suresh, Johnny Johnson, Mary C Wyatt and Chellu S Chetty. 2011.Influence of Environmental Phytoestrogens in Nutrition and Healthpublished in a book " Environmental Pollution, Ecology and Human Health ",  NAROSA publication, Eds:  Gottipolu RR et al. 97-108
Awards and Honours
  1. NIH-Visiting Scientist Fellowship, to USA during 2014-2015 for one year
  2. NIN-Visiting Research Scientist Fellowship to  USA during 2010-2012 for two years.
  3. ICMR Young Bio-medical scientist Fellowship for the years 2014-2015; visited USA for six months.
  4. Qualified GLP personnel for the NGCMA, Ministry of Science and Technology, Govt of India.
  5. CPCSEA Nominee for animal ethics from Ministry of Environment and forests, Govt of India
  6. Awarded with Doctor of Science (D.Sc.,) in Biotechnology during the year 2020 by Berhampur University, for the research work entitled “Deleterious effects of Lead and amyloid peptides and their toxic mechanisms in human brain cells”.