Dr. SUDHAKAR REDDY VADDE

SCIENTIST 'B', 
Biochemistry


Email:  sudhakarr.v@icmr.gov.in
Contact:  +91-40-27197293

Brief Profile
I received M.Sc. Genetics from Osmania University in 2008 and PhD, Biochemistry from Osmania University in 2015. I did postdoctoral research at the Cincinnati Children’s Hospital & Medical Center (CCHMC) in the area of Cystic Fibrosis for short span. Then, I joined the National Institute of Nutrition in November 2016 as a Scientist-B. My research interests include maternal protein restriction, vitamin B12, understanding the impact of dietary factors and functional foods on metabolic disorders such as diabetes and obesity, Besides, I am also working on to understand the role of chaperones, and protein quality control in diabetes and obesity. I was awarded JRFs from ICMR, UGC and National-PDF, DR. D.S. Kotari-PDF, PDF from CCHMC.
Total publications : 13; Publications in last 10 years
  1. Kishore KG, Reddy SS, Reddy PY, Kumar UC, Reddy VS, Ayyagari R, Reddy GB. (2019) Role of sorbitol-mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 679; https://doi.org/10.1016/j.abb.2019.108207. (PMID-31760123).
  2. Reddy VS*, Jamma T, Reddy GB*. (2019) Implication of Homocysteine in protein quality control processes. Biochimie, 165, 19-31 (*equal corresponding author) (PMID-31269461).
  3. Reddy VS, Palika R, Ismail A, Pullakhandam R, Reddy GB. (2018) Nutrigenomics: Opportunities & challenges for public healthy nutrition. Indian J of Med Res 148 (5), November 2018, pp 632-641, DOI: 10.4103/ijmr.IJMR_1738_18. (PMID-30666988).
  4. Reddy VS*, Madala SK, Jamma T, Reddy GB*. (2018) Extracellular small heat shock proteins: exosomal biogenesis and function. Cell stress and Chaperones. May;23(3):441–454, DOI 10.1007/s12192-017-0856-z. (*equal corresponding author) (PMID-29086335)
  5. Raghu G, Akileshwari C, Reddy VS, Reddy GB. (2017) Attenuation of diabetic retinopathy in rats by ellagic acid through inhibition of AGE formation. J Food Sci Technol. Jul;54(8):2411-2421 PMID-28740299).
  6. Noolu B, Gogulothu R, Bhat M, Qadri SS, Reddy VS, Reddy GB, Ismail A. (2016) Invivo inhibition of Proteasome activity and tumor growth by Murraya koenigii leaf extract in breast cancer xenografts and by its active flavonoids in breast cancer cell lines. Anticancer Agents Med Chem. 16(12):1605-1614. (PMID-27198988).
  7. Shrivastava, S., Jeengar, MK., Reddy, VS., Reddy, GB., & Naidu, VG. (2015). Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways. Exp Mol Pathol, 98(3), 313-27 (PMID-25818165)
  8. Reddy, VS., & Reddy, GB. (2016). Role of crystallins in diabetic complications. Biochim Biophys Acta - Gen Sub, 1860 (1), 269–277. (PMID-25988654).
  9. Moon, C., Zhang, W., Sundaram, N., Yarlagadda, S., Reddy, VS., Arora, K., Helmrath, MA., Naren, AP. (2015) Drug-induced secretory Diarrhea: A role for CFTR. Pharmacol Res.102, 107-112. (PMID-26429773).
  10. Reddy, VS., & Reddy, GB. (2015). Emerging role for αB-crystallin as a therapeutic agent: pros and cons. Curr Mol Med, 15(1), 47-61. (PMID-25601468).
  11. Reddy, VS., Jakhotia, S., Reddy, PY., &Reddy, GB. (2015) Hyperglycemia induced expression, phosphorylation, and translocation of αB-crystallin in rat skeletal muscle. IUBMB Life, 67(4), 291-9. (PMID- 25900025).
  12. Reddy, SS., Shruthi, K., Reddy, VS., Raghu, G., Suryanarayana, P., Giridhiran, N., & Reddy, GB. (2014) Altered ubiquitin proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochim Biophys Acta- Gen Sub, 1840 (9), 2924-2934. (PMID-24949983)
  13. Reddy, VS., Kumar, CU., Raghu, G., & Reddy, GB. (2014). Expression and Induction of Small Heat Shock Proteins in rat heart under chronic hyperglycemic conditions. Arch Biochem Biophys, 558C: 1-9. (PMID-24950024).
  14. Reddy, VS., Kumar, CU., & Reddy, GB. (2014). Effect of Chronic Hyperglycemia on crystallin levels in rat lens. Biochem Biophys Res Commun, 446 (2), 602-7. (PMID-24632206).
  15. Reddy, VS., Raghu, G., Reddy, SS., Kumar, PA., Suryanarayana, P., & Reddy, GB. (2013). Response of Small Heat Shock Proteins in diabetic rat retina. Invest Ophthalmol Vis Sci, 54 (12):7674-7682. (PMID-24159092)
  16. Vakdevi, V., Reddy, VS., Srinivas, PNBS., Mueller, NH., Bhagyalaxmi, SG., Padma, T., Petrash, JM., & Reddy, GB. (2011). Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: Molecular basis for early onset of age-related cataract. FEBS letters, 585 (24), 3884-9. (PMID-22085609).
Awards and Honors
  1. JRF Award by Indian Council of Medical Research
  2. JRF and Lectureship Award by UGC
  3. SRF Award by UGC
  4. Certificate of Merit for Oral Presentation in Asia-ARVO, New Delhi. October 28-31, 2013
  5. International Travel Grant award by DST-SERB
  6. PDF award from Cincinnati Children’s Hospital Medical Center (CCHMC), Cincinnati, Ohio
  7. N-PDF award by SERB
  8. D.S. Kothari Postdoctoral fellowship award by UGC
  9. Early Career Research award by SERB
  10. Associate Fellow, Telangana Academy of Sciences
  11. Travel grant for Young Investigator Meeting by India Bioscience, Mahabalipuram, India.