DR. SUDHAKAR REDDY VADDE

M.Sc., PhD
SCIENTIST-D
BIOCHEMISTRY


Email:  sudhakarr.v@icmr.gov.in
Contact:  +91-40-27197293

Brief Profile
Dr. V. Sudhakar Reddy completed his doctoral degree in Biochemistry from Osmania University in 2015. He did postdoctoral research at the Cincinnati Children's Hospital & Medical Center (CCHMC) in the area of Cystic Fibrosis for short span. He joined the institute in November, 2016. His research focused on metabolic health, and lifestyle-related non-communicable diseases (NCDs) including diabetes and obesity. His work spans fundamental mechanistic studies to translational interventions aimed at mitigating the complications of metabolic diseases through nutritional, molecular, and biochemical approaches. Additionally, he was also involved in public health nutrition research, focusing on the evaluation of nutritional interventions, including micronutrient supplementation and food fortification strategies, aimed at improving population health, reducing malnutrition, and mitigating the burden of NCDs in India. He is also recipient of numerous awards and fellowships, including the Research fellowships from ICMR and UGC, N-PDF from SERB, Early Career Research Award from SERB and the International Travel Grant from DST-SERB.
Total publications : 25
  1. Savitikadi P, Dash L, Angadi KK, Reddy GB, Reddy VS. Systemically administered mini α-crystallin peptide delays cataract progression in streptozotocin-induced diabetic rats. Biochimica et Biophysica Acta Gen Subj. 2025 Jun;1869(7):130814. doi: 10.1016/j.bbagen.2025.130814. Epub 2025 Apr 26. PMID: 40294808.
  2. Suryavanshi U, Marka N, Mallu ACT, Reddy GB, Reddy VS. Vitamin B12 supplementation attenuates endoplasmic reticulum stress and neuronal cell death in the cerebral cortex of high-fat high-sucrose-fed male mice. Nutrition. 2025 Apr 14;138:112808. doi: 10.1016/j.nut.2025.112808. Epub ahead of print. PMID: 40499198.
  3. Suryavanshi U, Angadi KK, Reddy VS*, Reddy GB*. Neuroprotective role of vitamin B12 in streptozotocin-induced type 1 diabetic rats. Chem Biol Interact. 2024 Jan 5;387: 110823. doi: 10.1016/j.cbi.2023.110823. Epub 2023 Dec 2. PMID: 38049026. (*corresponding author)
  4. Mahajan H, Mallinson PAC, Lieber J, Bhogadi S, Banjara SK, Reddy VS, Reddy GB, Kulkarni B, Kinra S. The Association of Total Meat Intake with Cardio-Metabolic Disease Risk Factors and Measures of Sub-Clinical Atherosclerosis in an Urbanising Community of Southern India: A Cross-Sectional Analysis for the APCAPS Cohort. Nutrients. 2024 Mar 5;16(5):746. doi: 10.3390/nu16050746. PMID: 38474874; PMCID: PMC10934090.
  5. Savitikadi P, Gogulothu R, Ismail A, Reddy GB, Reddy VS. Combined prenatal to postnatal protein restriction augments protein quality control processes and proteolysis in the muscle of rat offspring. J Nutr Biochem. 2023 Apr; 114:109273. doi: 10.1016/j.jnutbio.2023.109273. Epub 2023 Jan 18. PMID: 36681307.
  6. Reddy VS*, Reddy GB. Emerging therapeutic roles of small heat shock protein-derived mini-chaperones and their delivery strategies. Biochimie. 2023 May; 208:56-65. doi: 10.1016/j.biochi.2022.12.004. Epub 2022 Dec 12. PMID: 36521577. (*corresponding author)
  7. Reddy VS*, Reddy GB. Emerging therapeutic roles of small heat shock protein-derived mini-chaperones and their delivery strategies. Biochimie. 2023 May; 208:56-65. doi: 10.1016/j.biochi.2022.12.004. Epub 2022 Dec 12. PMID: 36521577. (*corresponding author)
  8. Reddy VS*, Pandarinath S, Archana M, Reddy GB*. Impact of chronic hyperglycemia on Small Heat Shock Proteins in diabetic rat brain. Arch Biochem Biophys. 2021 Apr 15; 701:108816. doi: 10.1016/j.abb.2021.108816. Epub 2021 Feb 23. PMID: 33631184. (*corresponding author)
  9. Eugene SP, Reddy VS, Trinath J. Endoplasmic Reticulum Stress and Intestinal Inflammation: A Perilous Union. Front Immunol. 2020 Nov 25; 11:543022. doi: 10.3389/fimmu.2020.543022. PMID: 33324392; PMCID: PMC7723926.
  10. Godisela KK, Reddy SS, Reddy PY, Kumar CU, Reddy VS, Ayyagari R, Reddy GB. Role of sorbitol- mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 2020 Jan 15; 679:108207. doi: 10.1016/j.abb.2019.108207. Epub 2019 Nov 21. PMID: 31760123.
  11. Reddy VS*, Trinath J, Reddy GB*. Implication of homocysteine in protein quality control processes. Biochimie. 2019 Oct; 165:19-31. doi: 10.1016/j.biochi.2019.06.017. Epub 2019 Jun 30. PMID: 31269461. (*corresponding author)
  12. Reddy VS, Palika R, Ismail A, Pullakhandam R, Reddy GB. Nutrigenomics: Opportunities & challenges for public health nutrition. Indian J Med Res. 2018 Nov;148(5):632-641. doi: 10.4103/ijmr.IJMR_1738_18. PMID: 30666988; PMCID: PMC6366269.
  13. Reddy VS*, Madala SK, Trinath J, Reddy GB*. Extracellular small heat shock proteins: exosomal biogenesis and function. Cell Stress Chaperones. 2018 May;23(3):441-454. doi: 10.1007/s12192-017- 0856-z. Epub 2017 Oct 30. PMID: 29086335; PMCID: PMC5904088. (*corresponding author)
  14. Raghu G, Akileshwari C, Reddy VS, Reddy GB. Attenuation of diabetic retinopathy in rats by ellagic acid through inhibition of AGE formation. J Food Sci Technol. 2017 Jul;54(8):2411-2421. doi: 10.1007/s13197-017-2683-8. Epub 2017 May 29. PMID: 28740299; PMCID: PMC5502036. (Impact Factor-1.281).
  15. Noolu B, Gogulothu R, Bhat M, Qadri SS, Reddy VS, Reddy GB, Ismail A. In Vivo Inhibition of Proteasome Activity and Tumour Growth by Murraya koenigii Leaf Extract in Breast Cancer Xenografts and by Its Active Flavonoids in Breast Cancer Cells. Anticancer Agents Med Chem. 2016;16(12):1605- 1614. doi: 10.2174/1871520616666160520112210. PMID: 27198988.
  16. Shrivastava S, Jeengar MK, Reddy VS, Reddy GB, Naidu VG. Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways. Exp Mol Pathol. 2015 Jun;98(3):313-27. doi: 10.1016/j.yexmp.2015.03.031. Epub 2015 Mar 26. PMID: 25818165.
  17. Reddy SS, Shruthi K, Reddy VS, Raghu G, Suryanarayana P, Giridharan NV, Reddy GB. Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochim Biophys Acta. 2014 Sep;1840(9):2924-34. doi: 10.1016/j.bbagen.2014.06.005. Epub 2014 Jun 17. PMID: 24949983.
  18. Reddy VS, Reddy GB. Role of crystallins in diabetic complications. Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):269-77. doi: 10.1016/j.bbagen.2015.05.009. Epub 2015 May 17. PMID: 25988654.
  19. Moon C, Zhang W, Sundaram N, Yarlagadda S, Reddy VS, Arora K, Helmrath MA, Naren AP. Drug- induced secretory diarrhea: A role for CFTR. Pharmacol Res. 2015 Dec; 102:107-112. doi: 10.1016/j.phrs.2015.08.024. Epub 2015 Sep 30. PMID: 26429773; PMCID: PMC4684461.
  20. Reddy VS, Reddy GB. Emerging role for αB-crystallin as a therapeutic agent: pros and cons. Curr Mol Med. 2015;15(1):47-61. doi: 10.2174/1566524015666150114112853. PMID: 25601468.
  21. Reddy VS, Jakhotia S, Reddy PY, Reddy GB. Hyperglycemia induced expression, phosphorylation, and translocation of αB-crystallin in rat skeletal muscle. IUBMB Life. 2015 Apr;67(4):291-9. doi: 10.1002/iub.1370. Epub 2015 Apr 22. PMID: 25900025.
  22. Reddy VS, Kumar ChU, Raghu G, Reddy GB. Expression and induction of small heat shock proteins in rat heart under chronic hyperglycemic conditions. Arch Biochem Biophys. 2014 Sep 15; 558:1-9. doi: 10.1016/j.abb.2014.06.008. Epub 2014 Jun 17. PMID: 24950024.
  23. Reddy VS, Kumar CU, Reddy GB. Effect of chronic hyperglycemia on crystallin levels in rat lens. Biochem Biophys Res Commun. 2014 Apr 4;446(2):602-7. doi: 10.1016/j.bbrc.2014.03.012. Epub 2014 Mar 12. PMID: 24632206.
  24. Reddy VS, Raghu G, Reddy SS, Pasupulati AK, Suryanarayana P, Reddy GB. Response of small heat shock proteins in diabetic rat retina. Invest Ophthalmol Vis Sci. 2013 Nov 19;54(12):7674-82. doi: 10.1167/iovs.13-12715. PMID: 24159092.
  25. Validandi V, Reddy VS, Srinivas PN, Mueller NH, Bhagyalaxmi SG, Padma T, Petrash JM, Reddy GB. Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataract. FEBS Lett. 2011 Dec 15;585(24):3884-9. doi: 10.1016/j.febslet.2011.10.049. Epub 2011 Nov 11. PMID: 22085609; PMCID: PMC4103624.
Book Chapters
  1. Reddy VS*, Jamma T, Reddy GB*. (2020). Small Heat Shock Proteins in Inflammatory Diseases. In: Asea, A.A.A., Kaur, P. (eds) Heat Shock Proteins in Inflammatory Diseases. Heat Shock Proteins, vol 22. Springer, Cham. https://doi.org/10.1007/7515_2020_9 (*corresponding author)
Conference Proceedings
  1. Reddy VS, Reddy GB. Role of small heat shock proteins in muscle under chronic hyperglycemia. FASEB Journal 2014 April, Volume 28, no.1 supplement 1102.42
  2. Reddy GB, Reddy SS, Reddy VS, Giridhiran NV. Dysregulated ubiquitin proteasome system leads to neurodegeneration in a spontaneous obese model. FASEB Journal 2014 April, Volume 28, no.1 supplement 559.1.
  3. Naidu VGM, Srivastava S, Jeengar MK, Kumar PS, Reddy VS, Reddy SS, Reddy GB. P2 Cardamonin suppresses the proliferation of gastric cancer cells by promoting β-catenin degradation. European Journal of cancer 2014 March, Volume 50, Supplement 1, page S9.
Awards and Honors
  1. JRF Award by Indian Council of Medical Research (not availed)
  2. JRF and SRF Award by UGC
  3. Certificate of Merit for Oral Presentation in Asia-ARVO-2013, New Delhi.
  4. International Travel Grant by DST-SERB to attend Experimental Biology conference-2014, USA
  5. National-PDF award by SERB.
  6. Dr. D.S. Kothari Postdoctoral fellowship (high fellowship) award by UGC (not availed)
  7. Early Career Research award by SERB
  8. Associate Fellow, Telangana Academy of Sciences
  9. Participant of Young Investigator Meeting by India Bioscience, Mahabalipuram, India.
  10. International Travel Grant award by DST-SERB to attend CSHL meeting-2020, USA