Scientist ‘G’
Molecular Biology

Contact:  +91-40-27197230

Brief Profile

His laboratory is involved in understanding the implications of gene-nutrient interaction and cell to cell cross talks in the development of obesity and associated complications like insulin resistance. It has been observed that in a diet induced obesity model of mouse the immune cells like macrophages and T cells infiltrate into the adipose tissue. His group is trying to understand the molecular mechanisms that recruit these cells into the adipose tissue as well as how these cells are activated and contribute in development of inflammation and consequently insulin resistance in the adipose tissue. His group is also studying how the metabolic stress is translated into inflammation at the endoplasmic reticulum through ER stress.
His group is also studying cell to cell cross talks involved zinc homeostasis. His group is also involved in the development of functional food and nutraceuticals. In addition, his group is studying molecular events in host-pathogen interaction and regulatory role of nutrients for such interactions.
His laboratory utilizes cutting edge technologies like real time PCR and Next Generation sequencing to study these mechanisms. His laboratory is supported by grants from DST, DBT and ICMR.

Total publications : 45 ; List of Publications (Last 10 years)
  1. Choudhury DR, Nair KM, Balakrishna N, Radhakrishna, KV, Ghosh S, Rao SF. Food synergy approach in a national program to improve the micronutrient status of preschoolers—randomized control trial protocol. Ann NY Acad Sci. 2018, (in press) IF 4.039
  2. Singh P, Nagender R, Ghosh S, and Mukhopadhyay S Cell envelope lipids in the pathophysiology of Mycobacterium tuberculosis. Future Microbiology, 2017,(in Press) doi: 10.2217/fmb-2017-0135 IF 3.374
  3. Jeyapal S, Putcha UK, Mullapudi VS, Ghosh S, Sakamuri A, Kona SR, Vadakattu SS, Madakasira C and Ibrahim A. Chronic consumption of fructose in combination with trans fatty acids but not with saturated fatty acids induces nonalcoholic steatohepatitis with fibrosis in rats.Eur J Nutr.2017, (in press) IF 4.370
  4. Joshi AKR, Kandlakunta, B. Kotturu SK and Ghosh. S. (2018) Antiglucocorticoid potential of nutraceuticals: In silico molecular docking and in vitro assessment.  J Food Biochemistry 000:000 (in Press) IF 0.815
  5. Sasikala M, Ravikanth VV, Manohar KM, Deshpande D, Singh S, Kumar PP, Talukdar R,  Ghosh S, Aslam A, Rao GV,  Pradeep R,  and Reddy DN. Bach2 repression mediates Th17 cell induced inflammation and associates with clinical features of advanced disease in chronic pancreatitis. United European Gastroenterology, 2017, (in press) IF 3.477
  6. Mukhopadhyay S. and Ghosh S. Mycobacterium tuberculosis: what is the role of PPE2 during infection? Future Microbiology, 2017, 12: 457-460. IF 3.374
  7. Bhat, KH, Srivastava S, Kotturu SK, Ghosh S, and Mukhopadhyay S. (2017) The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production. Scientific  Reports, 2017, 7:39706 IF: 5.578
  8. Singh P, Rao RN, Reddy JRC, Prasad RBN, Kotturu SK, Ghosh S, and Mukhopadhyay S. (2016) PE11, a PE/PPE family protein of Mycobacterium tuberculosis is involved in cell wall remodeling and virulence. Scientific Reports, 2016, 6:21624 IF: 5.578
  9. Mashurabad PC, Kondaiah P, Palika R, Ghosh S, Nair MK and Raghu P.Eicosapentaenoic acid inhibits intestinal β-carotene absorption by downregulation of lipid transporter expression via PPAR-α dependent mechanism. Arch BiochemBiophys, 2015,  590:118-124 IF: 3.017
  10. Rasheedi S, Suragani M, Raviprasad P, Ghosh S,  Suragani R,  Ramaiah K, and Ehtesham NZ. Functional characterization of Peif5B as eif5B homologue from Pisumsativum.Biochemeie,2015, 118:36-43 IF:2.963
  11. Patwardhan S, Dasari S, Bhagavatula K, Steffen M, Deepak SA, Ghosh S, and Basak S. Simultaneous detection of genetically modified events in a mixture by multiplex PCR-microchip capillary electrophoresis. J AOAC Int, 2015,  98:1366-74IF : 1.233
  12. Nimgulkar C, Ghosh S,  Anand BS,  Kumar PU,  Surekha MV, Madhusudhanachary P, Annapurna B R, Bharadwaj BD. Combination of spices and herbal extract restore macrophage foam cell migration and abrogate atheroinflammatory signaling cascade of atherogenesis. Vascular Pharmacology,2015,  72:53-63 IF: 3.635
  13. Sreejit G, Ahmed A, Parveen N, Jha V, Valluri VL, Ghosh S, and Mukhopadhyay S. The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage. PLoS Pathogen, 2014,  10(10):e1004446 IF: 8.136
  14. Parveen N, Varman R, Das G, Ghosh S, and Mukhopadhyay S. Endocytosis of Mycobacterium tuberculosis heat shock protein 60 is required to induce interleukin-10 production in macrophages.  J BiolChem, 2013, 288(34):24956-71 IF 5.328
  15. Nimgulkar CC, Anand SB, Kumar UP, Ghosh S, and Kumar, DB. Poly herbal formulation prevents foam cell formation possibly through attenuation of CD36 scavenger receptor signaling cascade. Arterioscl. Thromb. Vasc. Biol., 2013,  33:A250 IF:6.338 (2013)
  16. Basak S, Ehtesham NZ, Sesikeran B and Ghosh S. (2014) Detection and identification of transgenic elements by fluorescent-PCR based capillary gel electrophoresis in genetically modified cotton, and soybean. J AOAC Int, 2014,  97:159-165 IF : 1.233
  17. Pullakhandam R, Palika R, Ghosh S, Reddy GB. Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: the significance of transthyretin. IUBMB Life, 2012, 64:975-982. IF: 2.789
  18. Shankar P, Ghosh S, Bhaskarachary K, Venkaiah K, Khandare, AL. Amelioration of  chronic fluoride toxicity by calcium and fluoride-free water in rats. Br J Nutr, 2012, 11:1-10. IF: 3.013 (2011)
  19. Bhat KH, Chaytanya CK,  Parveen N,  Varman R,  Ghosh S, and Mukhopadhyay, S. Proline-proline-glutamic acid (PPE) protein Rv1168c of Mycobacterium tuberculosis augments transcription from HIV-1 LTR promoter. J BiolChem, 2012, 287:16930-46 IF:5.328
  20. Mukhopadhyay S, Nair S, and Ghosh S. Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets.FEMS Microbiol Rev, 2012, 36:463-85 IF: 11.796
  21. Sesikeran B, Polasa K, Vajreswari A, Raghunath M, Nair KM, Hemlatha R, Radhakrishna KV, Ghosh S,Sudershan Rao V, Vazir S, Fernandez S, and Raghu P. (2010) New Areas of Nutrition Research.NFI Bulletin, 2010, 31:1-6
  22. Nair S, Ramaswamy PA, Ghosh S, Joshi DC, Pathak N, Siddiqui I, Sharma P, Hasnain SE, Mande SC and Mukhopadhyay S. The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage. J Immunol., 2009,  15;183(10):6269-81 IF: 6.00
  23. Haseeb A, Iliyas L, Chakraborty S, Farooqui AR, Naik SR, Ghosh S, Suragani M, and Ehtesham, NZ. Single Nucleotide polymorphism in peroxisome proliferator-activated receptor-g2 and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population. J  Biosci. 2009,  34(3):405-14 IF:1.703
  24. Rasheedi S, Suragani M, Haq SK, Ghosh S, Ehtesham NZ, and Hasnain SE. (2010) Characterization of LEF4 ligand binding property and its role as part of baculoviral transcription machinery. Mol Cell Biochem, 2010, 333(1-2):83-9 IF: 1.764
  25. Rasheedi S, Suragani M, Haq SK, Ghosh S, Ehtesham NZ, and Hasnain SE. (2009) Biophysical characterization and unfolding of LEF4 factor of RNA polymerase from AcNPV. Biopolymers. 2009, 91(7):574-82. IF:2.823
  26. Aruna B, Islam A, Ghosh S, Singh AK, Vijayalakshmi M, Ahmad F and Ehtesham NZ. Biophysical analyses of human resistin: oligomer formation suggests novel biological function. Biochemistry, 2008, 47(47):12457-66. IF:3.379

1. Jain, A., Ranjan, A., Chatterji, U., Das, P., Ghosh, S., Habib, S., Pandey S., Ramachandran, A., Venkaiah, B., and Hasnain, S.E. (1997) High level of expression of heterologous genes in insect cells is not dependent on promoters alone. In; Invertebrate Cell Culture: Novel directions and biotechnol-ogy applications (Ed. K. Marmorosch and J. Mitsuhashi), Academic Press, New York pp 221-227.

Patents filed

1. Katoch, V.M., Ghosh, S. , Chauhan, D.S., Parashar, D., Singh, D. and Sharma, V.D. (2007) Novel primers for a PCR-RFLP assay for identification of pathogenic Mycobacteria.
2. Ghosh, S. and Hasnain S.E. (2002) A novel method for enhancing solubility of the expressed pro-teins in E. coli

Awards and Honors
  1. AMBO (Asian Molecular Biology Organization)Fellowship, 1998
  2. DBT Post Doctoral Fellowship, 2001
  3. DST Young Scientist Award, 2003
  4. BOYSCAST Fellowship, 2004