Dr. Vakdevi Validandi

Scientist 'D', 
Food Toxicology Division


Email:  vaagdevi@gmail.com
Contact:  +91-40 27197391

Brief Profile

Dr. Vakdevi Validandi, Ph.D in Biochemistry, joined as scientist-B in 2012. Her research area of interests is mycotoxin research. She is trying to develop and validate the HPLC/LCMS MS methods for the estimation of aflatoxin B1 biomarker (Aflatoxin B1-lysine adduct) in the serum samples. She is working on the mycotoxin contamination levels in the various commonly consumed food items and herbal medicines and assess the human health risk associated with the consumption of mycotoxin contaminated foods.
Total publications : 25
  1. Vakdevi Validandi,*Arjun L Khandare,  Srinivas Dheeravath, Sureka Mullapudi Venkata, Srinivasu Kurella, Sukesh Narayan Sinha. Nutritional, biochemical, and histopathological study on dose and time dependent effects in fluoride exposed rats. (In press), Fluoride (I.F:- 1.224)
  2. Balaji Gouda, Sukesh Narayan Sinha, Meram Chalamaiah , Validandi Vakdevi, Patangay Shashikala, Bantal Veeresh, Venkata Mullapudi Surekha, Vasudev Kasturi  and Naveen Kumar Boiroju. Sex Differences in animal models of sodium-valproate-induced autism in postnatal balb/cmice: whole-brain histoarchitecture and 5-HT2A receptor biomarker evidence. Biology, 2022, 11, 79. https://doi.org/10.3390/biology11010079. (I.F: 5.079)
  3. Arjun L Khandare,Vakdevi Validandi, Ravi Prakash Jamalpur, Srinivas Dheeravath, Srinivasu Kurella, Anitha Chauhan, Naveen kumar Boiroju, Longvah Thingnganing. Potential health risks associated with the heavy metals content in commonly consumed food from Prakasam district of Andhra Pradesh, India. Biological Trace Element Research, 2021. https://doi.org/10.1007/s12011-021-02918-5 (IF. 3.738)
  4. Vakdevi Validandi, Ankita Darekar, Virendra Panpatil, Arjun L Khandare. Ameliorative potential of tamarind fruit extract on sodium fluoride–induced alterations in the bone parameters in Saos-2 cell line. Fluoride, 2021; 54(2):102-110 (I.F: 1.224)
  5. Arjun Lakshman Khandare, Vakdevi Validandi, Ananthan Rajendran, Toteja Gurudayal Singh, Longvah Thingnganing, Srinivasu Kurella, Raju Nagaraju, Srinivas Dheeravath, Nagaraju Vaddi, Srinivasulu Kommu, Yadaiah Maddela. Health risk assessment of heavy metals and strontiumin groundwater used for drinking and cooking in 58 villages of Prakasam district, Andhra Pradesh, India. Environmental Geochemistry and Health, 2020, 42:3675-3701. DOI:https://doi.org/10.1007/s10653-020-00596-1. (I.F: 3.472)
  6. Priyanka Shankar, Arjun L. Khandare, Vakdevi Validandi, Sujata Khandare. Supplementation of calcium and fluoride-free water mitigates skeletal fluorosis in fluoride-intoxicated rats. Biological Trace Element Research, 2020, 199(6), 2225-2237 DOI: https://doi.org/10.1007/s12011-020-02326-1 (I.F:2.450)
  7. Arjun L Khandare, Kalakumar B, Vakdevi Validandi, Qadri SSYH, Harishankar N, Surya S. Singh, Venkaiah Kodali. Neurolathyrism in goat (Capra hircus) kid: Model development. Research in Veterinary Science, 2020, 132, 49-53 DOI: https://doi.org/10.1016/j.rvsc.2020.05.019 (I.F:1.892)
  8. Vakdevi Validandi, Gopalan Viswanathan and Arjun L Khandare. Comparison of fluoride levels (total and extracted) in young, old tea leaves and market tea samples along with impact of tea infusion on dental fluorosis in fluoride endemic villages of Nalgonda District, India. Advances in Dentistry and Oral Health, 2019; 10(4) 1-8. (I.F: 1.092)
  9. Hari Kumar R, Arjun L Khandare , Laxmaiah A, Meshram II, Arlappa N, Vakdevi Validandi, Venkaiah K, Amrutha Rao P., Sunu P.V,.Bhaskar V., Toteja G.S. Prolonged consumption of grass pea (64 g/Cu/day) along with millets and other cereals causes no Neurolathyrism.  . Nutritional Neuroscience, 2019 22:1-8 (I.F: 3.950)
  10. Arjun L. Khandare, Vakdevi Validandi, Naveen Boiroju. Fluoride alters serum elemental (Calcium, Magnesium, Copper, and Zinc) homeostasis along with erythrocyte carbonic anhydrase activity in fluorosis endemic villages and restores on supply of safe drinking water in school-going children of Nalgonda District, India. Biological Trace Element Research, 2018 185(2):289-294 (I.F: 2.361)
  11. Arjun L. Khandare, Vakdevi Validandi, Shankar Rao Gourineni, Viswanathan Gopalan, Balakrishna Nagalla. Dose-dependent effect of fluoride on clinical and subclinical indices of fluorosis in school going children and its mitigation by supply of safe drinking water for 5 years: an Indian study. Environmental Monitoring and Assessment, 2018, 190:110. (I.F: 1.804).
  12. Arjun L Khandare, Vakdevi Validandi, Munikumar Manne, G Bhanuprakash Reddy, Uday Kumar Putcha, Shankar Rao Gourineni, Balakrishna Nagalla. Tamarind fruit extract ameliorates fluoride toxicity by upregulating carbonic anhydrase II: a mechanistic study. Fluoride, 2018 51(2)137–152 (I.F: 1.342).
  13. Munikumar Manne, Vakdevi Validandi, Arjun L Khandare. Reduction of fluoride toxicity by tamarind components: an in silico study. Fluoride, 2018 51(2)122–136 (I.F: 1.342).
  14. Arjun L Khandare, Vakdevi Validandi, Gopalan Viswanathan, G Shankar Rao, N Balakrishna. Role of carbonic anhydrase and triiodothyronine in dental caries affected children in fluorosis endemic areas. Advances in Dentistry and Oral Health. 2018. (I.F: 1.092).
  15. Arjun L. Khandare, R. Hari Kumar, I.I. Meshram, N. Arlappa, A. Laxmaiah, K. Venkaiah, P. Amrutha Rao, Vakdevi Validandi, G.S. Toteja. Current scenario of consumption of Lathyrus sativus and lathyrism in three districts of Chhattisgarh State, India. Toxicon,  2018 150:228-234. (I.F: 2.492).
  16. Vakdevi Validandi, Shankar Rao Gourineni, Srinivas Dheeravath, Balakrishna Nagalla, Arjun L Khandare. Tamarind supplementation ameliorates the high fluoride induced glucose intolerance and insulin resistance in rats.. Fluoride, 2017, 50(3) 314–323. (I.F: 1.342).
  17. Arjun L Khandare, Shankar Rao Gourineni, Vakdevi Validandi. Dental fluorosis, nutritional status, kidney damage and thyroid function along with bone metabolic indicators in school going children living in fluoride affected hilly areas of Doda district, Jammu and Kashmir, India.. Environmental Monitoring and Assessment, 2017 189(11):579. (I.F: 1.804).
  18. Shyam Prasad G, Govardhan P,  Deepika G, Vakdevi V,  Sashidhar R.B.  Anti‑inflammatory activity of anti‑hyperlipidemic drug, fenofibrate,and its phase‑I metabolite fenofibric acid: in silico, in vitro, and in vivo studies. Inflammopharmacology, 2018; 26, 973–981 (I.F: 3.304).
  19. Rama Krishna, Shyam Perugu, S.N. Sinha, Vakdevi Validandi. Drug repositioning of the gallate group from EGCG for the repurposing. European Journal of Pharmaceutical and Medical Research, 2016; 3(7) 253-262. (I.F: 3.628).
  20. Arjun L Khandare Vakdevi Validandi, Shanker Rao, Balakrishna Nagalla. Effects of strontium and fluoride on bone mechanical and biochemical indices in guinea pigs (Caviaporcellus). Fluoride, 2015; 48(2)137-147. (I.F: 0.931)
  21. ArjunL Khandare, Vakdevi Validandi, Shanker Rao, Srinivas Dheeravath, Balakrishna Nagalla. Synergistic effects of strontium and fluoride on nutritional status in guinea pigs (Caviaporcellus). Fluoride, 2015; 48(4) 283-292.(I.F:0.931)
  22. Reddy PY, Giridharan NV, Balakrishna N, Vakdevi Validandi,  Raghu Pullakhandam,  Bhanuprakash Reddy G. Increased risk of cataract development in WNIN-Obese rats due to accumulation of intra-lenticular sorbitol. IUBMB Life, 2013; 65 (5), 472-478. (I.F:3.514)
  23. Validandi V, Reddy VS, Srinivas PN, Mueller NH, Bhagyalaxmi SG, Padma T, Petrash JM, Reddy GB. Temperate-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataract. FEBS Letters,  2011; 585(24):3884-9. (I. F: 3.538)
Awards and Honors

1. Awarded Young Scientist (Senior) Award in Experimental Nutrition at the 48th National Conference of the Nutritional Society of India during 4-5th November, 2016  held at St. Johns Research Institute, St. Johns National Academy of Health Sciences, Bangalore. Topic of the paper: Tamarind ameliorates the fluoride induced glucose intolerance and insulin resistance in rats